Quantification of triglycerides level in HCV infected cell lines within lipid droplets following epigenetic manipulation / Mennatallah Mamdouh Mahmoud Mahdy ; Supervised Ahmed Ihab Abdelaziz , Rasha Hanafi
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TextLanguage: English Publication details: Cairo : Mennatallah Mamdouh Mahmoud Mahdy , 2015Description: 106 Leaves : charts , photographs ; 30cmSubject(s): Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Background: Hepatitis C virus (HCV) is a major causative agent of non-alcoholic fatty liver disease (NAFLD) which is characterized by excessive accumulation of lipid droplets (LD) in the cytoplasm of the cells which the virus utilizes to promote its life cycle. MicroRNA-29a (miR-29a) is an antiviral, antifibrotic microRNA which was reported by biomformatics analysis to bind to the 3'UTR to an important prolipogenic transcription facor. Sterol regulatory element binding protein-lc (SREBP-lc) which is induced in response to HCV infection and promoted LD formance. One of its dowastream targets is caveolin-I (CAVI), an integral membrance protein associated with lipid droplets in certain conditions
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2015.Me.Q (Browse shelf(Opens below)) | Not for loan | 01010110072250000 |
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Background: Hepatitis C virus (HCV) is a major causative agent of non-alcoholic fatty liver disease (NAFLD) which is characterized by excessive accumulation of lipid droplets (LD) in the cytoplasm of the cells which the virus utilizes to promote its life cycle. MicroRNA-29a (miR-29a) is an antiviral, antifibrotic microRNA which was reported by biomformatics analysis to bind to the 3'UTR to an important prolipogenic transcription facor. Sterol regulatory element binding protein-lc (SREBP-lc) which is induced in response to HCV infection and promoted LD formance. One of its dowastream targets is caveolin-I (CAVI), an integral membrance protein associated with lipid droplets in certain conditions
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