Potential predictors of atrial fibrillation recurrence secondary to substrate electrophysiological and structural remodelling in patients having 3D guided catheter ablation and electrical cardioversion / Michael Sobhy Naguib ; Supervised Mohamed Ali Hamoda , Ahmed Abdalaziz , Mohamed Magdy Abbas

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Michael Sobhy Naguib

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TextLanguage: English Publication details: Cairo : Michael Sobhy Naguib , 2016Description: 192 P. : charts , facsimiles ; 25cmOther title:

دراسة المؤشرات المحتملة لتنبؤ ارتداد الارتجاف الأذينى الناشئ عن الخلل الكهروفسيولوجى و التكوينى لمرضى الارتجاف الأذينى بعد الكى باستخدام قسطرة المسح ثلاثى الأبعاد و بعد الصدمات الكهربائية [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine Summary: The pathogenesis of atrial fibrillation (AF) remains incompletely understood and management remains difficult and complex task. There is growing research work aiming at identifying role of different variables in predicting AF recurrence following treatment with the different currently available therapeutic options. This study sought to explore the predictor role of some variables, especially the role of C- reactive protein (CRP) and estimated glomerular filtration rate (eGFR), for recurrence of AF in patients with paroxysmal atrial fibrillation (AF) treated by electrical cardioversion (CV) and antiarrhythmic drugs (AAD) as well as in patients treated by catheter ablation. 120 paroxysmal AF patients with structurally normal heart by echocardiography divided into 3 groups each contain 40 consecutive patients according to the planned therapeutic intervention CV and AAD, radiofrequency (RF) PVI and cryoballoon PVI were studied for potential predictors of AF recurrence, especially CRP and eGFR. Pretreatment assay was calculated and all patients were followed up for 12 months following treatment for incidence of AF recurrence. Patients with high levels of CRP showed consistent higher risk of AF recurrence over 12 months period follow up when RF PVI (83.3% with high CRP versus 17.7% with normal CRP) as well as AADs and electrical CV (94.4% with high CRP versus 54.6% with normal CRP) treatment regimens were followed (p values < 0.001 and 0.005) respectively. However, this risk was insignificant in patients treated with cryoballoon PVI (28.6% versus 24.2%, p = 0.81). Low eGFR were associated with a borderline risk of AF recurrence in patients treated with AADs and electrical CV (91.7% versus 64.3%, p = 0.076). Yet, in those treated with RF PVI (18.2% versus 31%) or cryoballoon PVI (44.4% versus 19.4%) low GFR estimate was not associated with significant risk

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.09.Ph.D.2016.Mi.P (Browse shelf(Opens below))		Not for loan		01010110069439000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.09.Ph.D.2016.Mi.P (Browse shelf(Opens below))	69439.CD	Not for loan		01020110069439000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

The pathogenesis of atrial fibrillation (AF) remains incompletely understood and management remains difficult and complex task. There is growing research work aiming at identifying role of different variables in predicting AF recurrence following treatment with the different currently available therapeutic options. This study sought to explore the predictor role of some variables, especially the role of C- reactive protein (CRP) and estimated glomerular filtration rate (eGFR), for recurrence of AF in patients with paroxysmal atrial fibrillation (AF) treated by electrical cardioversion (CV) and antiarrhythmic drugs (AAD) as well as in patients treated by catheter ablation. 120 paroxysmal AF patients with structurally normal heart by echocardiography divided into 3 groups each contain 40 consecutive patients according to the planned therapeutic intervention CV and AAD, radiofrequency (RF) PVI and cryoballoon PVI were studied for potential predictors of AF recurrence, especially CRP and eGFR. Pretreatment assay was calculated and all patients were followed up for 12 months following treatment for incidence of AF recurrence. Patients with high levels of CRP showed consistent higher risk of AF recurrence over 12 months period follow up when RF PVI (83.3% with high CRP versus 17.7% with normal CRP) as well as AADs and electrical CV (94.4% with high CRP versus 54.6% with normal CRP) treatment regimens were followed (p values < 0.001 and 0.005) respectively. However, this risk was insignificant in patients treated with cryoballoon PVI (28.6% versus 24.2%, p = 0.81). Low eGFR were associated with a borderline risk of AF recurrence in patients treated with AADs and electrical CV (91.7% versus 64.3%, p = 0.076). Yet, in those treated with RF PVI (18.2% versus 31%) or cryoballoon PVI (44.4% versus 19.4%) low GFR estimate was not associated with significant risk

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