Effect of olmesartan on metabolic syndrome-induced Insult in rats / Ezz Eldin Abdelrahman Ahemed Abdelaziz ; Supervised Azza M. Agha , Mohammed F. Elyamany , Mohammad Alshorbagy

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and toxicology

Background: Metabolic syndrome is a pathophysiological entity characterized by a clustering of insulin resistance, hyperinsulinemia, dyslipidemia, hypertension and obesity. Aims: The present study was undertaken to study the effect of olmesartan (OLM) and pioglitazone (PIO) on metabolic syndrome induced by fructose 10% in the rats. Methods: Male wistar rats were randomly assigned to 4 groups (n=20) as follows: Group I; control group, group II; given fructose 10%. The other two groups were treated with either PIO (10 mg/kg, p.o.) or OLM(10 mg/kg, p.o.), for 4 weeks, after induction by fructose 10% for 12 weeks. Before the last 3 days from the end experiment, the systolic blood pressure (SBP) was measured. Blood was then collected for determination of serum glucose, serum insulin, serum triglyceride, serum high density lipoprotein, serum total cholesterol, blood glutathione, serum thiobarbituric acid reactive substances, serum nitric oxide, serum alanine transaminase, serum aspartate transaminase. Serum C-reactive protein, serum tumor necrosis factor alpha and serum interleukin 1b were also assessed. Finally, rats were sacrificed and hearts were excised to quantify cardiac hypertrophy. Results: Treatment with PIO (10 mg/kg) and OLM (10 mg/kg) reduced systolic blood pressure, serum blood glucose and insulin levels. Also lipid profile was reduced compared to untreated rats. Oxidative stress markers, as well as tumor necrosis factor alpha (TNF-Ü), interleukin1b, C-reactive protein, AST and ALT were all reduced as compared to untreated animals

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