Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Animal physiology

The objective of the present study was, to investigate the effect of oxidative stress induced by dizocilpine (MK-801); and the role of antioxidants such as vitamin C, vitamin E and olive pomace on body weight, spermiogram, behavior, oxidative and antioxidant status, hormonal, testicular enzyme markers, metabolic parameters, histomorphology of testes and reproductive performance of doe mated by rabbit bucks in first and second month of experiment. The bucks were equally and randomly divided into six groups (6 in each) namely; control which was injected with 1.0 ml sterile saline; second group was injected by dizocilpine at a dose 0.1mg/ kg. intraperitoneally (i.p.) for 5 consecutive days, the third group was subjected to dizocilpine and supplemented with 2vitamin C3 (1 g/ 1 L/ drinking water), 1 g contain 100 I.U vit C, while the forth group was subjected to dizocilpine and supplemented with 2vitamin E3 (50 ml/ 100 l of drinking water,1ml contain 20 I.U. vit E) and those of the fifth group was supplemented with 2vitamin C3plus2 vitamin E3. All five groups were fed the same basal diet, while the sixth group was subjected to dizocilpine and fed diet which contains olive cake meal (10%). Results in first month revealed (1) significant decrease in body weight, spermiogram, sex behavior, antioxidative parameters, testicular estradiol, testosterone, enzyme markers, total proteins and litter size and weight of doe mated with buck under dizocilpine oxidative stress, while an increase in prolactin level, glucose, cholesterol, triglycerides, urea, uric acid and creatinine with clear destructive change in testes of dizocilpine group, (2) Significant improvement of the measured parameters in groups subjected to dizocilpine and supplemented with 2vitamin E,2vitamin C3 and olive pomace

Issued also as CD