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Topical indocyanine green nanosystem for photodynamic therapy of cutaneous warts / Mohammed Najah Hasan Aldaraji ; Supervised Nevien Samy , Maha Fadel , Doaa Ahmed Abdelfadeel

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Najah Hasan Aldaraji , 2021Description: 181 P. : charts , facsimiles ; 25cmOther title:
  • الانذوسيانين الأخضر الوضعى فى النظام النانوى للعلاج الضوئى الديناميكى لثآليل الجلد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser Applications im Medical and Biolobical Summary: Background: Photodynamic therapy was proven very promising for the treatment of dermatological diseases, especially the resistant ones such as recalcitrant cutaneous warts. Objective: To evaluate the efficacy and safety of photodynamic treatment of cutaneous warts using ICG carried in a Nano system drug carrier and prepared in a topical form (gel) as a photosensitizer in combination with diode laser as a source of radiation. Methods: The efficiency of the nano-vesicular system (transethosomes) as a potential topical drug delivery system for the photosensitizer indocyanine green (ICG) was investigated followed by clinical photodynamic therapy (PDT) in patients suffering from cutaneous warts. Results: Results revealed that ICG transethosomal gel displayed curative effects which were excellent in 19 cases, good in 9 cases and poor in 2 cases only. It also showed that recurrence was in only one case out of the total 30 cases with highly significant difference of dermatology life quality index DLQI before and after total treatment sessions and the mean of degree of improvement was (4.90 ± 1.09). Conclusion: PDT using transethosomal ICG is an effective and safe therapeutic modality for the treatment of cutaneous warts
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.Ph.D.2021.Mo.T (Browse shelf(Opens below)) Not for loan 01010110084389000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.Ph.D.2021.Mo.T (Browse shelf(Opens below)) 84389.CD Not for loan 01020110084389000

Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser Applications im Medical and Biolobical

Background: Photodynamic therapy was proven very promising for the treatment of dermatological diseases, especially the resistant ones such as recalcitrant cutaneous warts. Objective: To evaluate the efficacy and safety of photodynamic treatment of cutaneous warts using ICG carried in a Nano system drug carrier and prepared in a topical form (gel) as a photosensitizer in combination with diode laser as a source of radiation. Methods: The efficiency of the nano-vesicular system (transethosomes) as a potential topical drug delivery system for the photosensitizer indocyanine green (ICG) was investigated followed by clinical photodynamic therapy (PDT) in patients suffering from cutaneous warts. Results: Results revealed that ICG transethosomal gel displayed curative effects which were excellent in 19 cases, good in 9 cases and poor in 2 cases only. It also showed that recurrence was in only one case out of the total 30 cases with highly significant difference of dermatology life quality index DLQI before and after total treatment sessions and the mean of degree of improvement was (4.90 ± 1.09). Conclusion: PDT using transethosomal ICG is an effective and safe therapeutic modality for the treatment of cutaneous warts

Issued also as CD

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