Comparison of the effect of topical lidocaine and verapqamil on vessel diameter in microsurgery : An experimental study in rats / Mostafa Edris Abdulazim Soliman ; Supervised Ashraf Abolfotooh Khalil , Shaimaa Mostafa Abass , Rama Ahmed Ali

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Mostafa Edris Abdulazim Soliman

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TextLanguage: English Publication details: Cairo : Mostafa Edris Abdulazim Soliman , 2018Description: 65 P. : charts , facsimiles ; 25cmOther title:

المقارنة بين التأثير الموضعي لليدوكاين و ال{u٠٦ء٤}يراباميل على قطر الاوعية في الجراحة الميكروسكوبية : دراسة تجريبية على الفئران [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of General Surgery Summary: Despite the development and experience with free tissue transfer and replantation and high success rates, intraoperative vasospasm continues to be common, often unpredictable, and potentially affecting flap survival in microvascular surgery. Vasospasm is caused mainly by intraoperative dissection and manipulation of small-caliber blood vessels, which is inevitable in microsurgery and is estimated to affect between 5 and 10 percent of all microsurgical procedures. One of the well-known methods to deal with vasospasm is the application of topical vasodilating agents. There are currently many medications that can be used, but no standard algorithm exists. Drug choice is based on anecdotal evidence or personal training.The purpose of this study is to compare the local effect of lidocaine and verapamil on the femoral vessel diameter in a rat model to reach the optimal vasodilating agent to use in microsurgery.21 Sprague-Dawley rats (42 femoral arteries) were divided into 21 artery in each group of verapamil and lidocaine, diameter of the vessel was measured before topical application of the drugs, 5 minutes after application and after anastomosis

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.14.M.Sc.2018.Mo.C (Browse shelf(Opens below))		Not for loan		01010110077535000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.14.M.Sc.2018.Mo.C (Browse shelf(Opens below))	77535.CD	Not for loan		01020110077535000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of General Surgery

Despite the development and experience with free tissue transfer and replantation and high success rates, intraoperative vasospasm continues to be common, often unpredictable, and potentially affecting flap survival in microvascular surgery. Vasospasm is caused mainly by intraoperative dissection and manipulation of small-caliber blood vessels, which is inevitable in microsurgery and is estimated to affect between 5 and 10 percent of all microsurgical procedures. One of the well-known methods to deal with vasospasm is the application of topical vasodilating agents. There are currently many medications that can be used, but no standard algorithm exists. Drug choice is based on anecdotal evidence or personal training.The purpose of this study is to compare the local effect of lidocaine and verapamil on the femoral vessel diameter in a rat model to reach the optimal vasodilating agent to use in microsurgery.21 Sprague-Dawley rats (42 femoral arteries) were divided into 21 artery in each group of verapamil and lidocaine, diameter of the vessel was measured before topical application of the drugs, 5 minutes after application and after anastomosis

Issued also as CD

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