Antiulcerogenic activity of vitis vinifera leaves extract in male albino rats / Nagat Saleh Hussein Altaorgay ; Supervised Amel Mahmoud Ali Soliman , Sohair Ramadan Fahmy , Dawlet Ahmed Sayed

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

The present work aimed to investigate the prophylactic and the curative antiulcerogenic efficacy of Vitis vinifera leaves (VVE) in comparison with the standard chemical drug ranitidine (RAN), using indomethacin and cold stress to induce sever gastric ulcer (SGU) model in healthy rats. Forty rats were randomly assigned into four main groups. Rats of the first (control) group administered distilled water orally. Rats of the second group (SGU group) administered single oral dose of indomethacin (150 mg/kg) and exposed to cold stress. Rats of the third (prophylactic) group were assigned into three subgroups treated with VVE (500 mg/kg, o.p), RAN (50 mg/kg, o.p) and VVE+RAN and then exposed to SGU. Rats of the fourth group (curative) were exposed firstly to SGU and then divided into 3 subgroups treated with VVE, RAN and VVE+RAN. The present work showed that administration of indomethacin with cold stress caused severe, hemorrhagic ulcers and histopathological alterations as well as lipid peroxidation and free radicals generation. The results demonstrated that pre-or post-treatment with VVE (500 mg/kg, o.p) and/or RAN (50 mg/kg, o.p) exhibit significant protecting effect on nearly all the studied parameters. Also histopathological examination showed an improvement in the stomach and duodenal architectures examination of the treated group compared to SGU group. Moreover, the study also demonstrated that the combination of VVE and ranitidine (especially in the post-treated groups) has more potent therapeutic effect on ulcer healing

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