Impact of the disease duration on diabetic patients type II using electrophysiological studies / Nagy Ahmed Abdelal Abou Querin ; Supervised Hebatallah Raafat Mohamed Rashad , Amira Ahmed Aly Labib , Alshaimaa Sobhi Khalil

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neurophysiology

Background: Diabetes mellitus (DM) is one of the most common clinical syndromes that is characterized by chronic hyperglycemia caused by relative or absolute insulin deficiency. Long standing metabolic derangement is associated with functional and structural changes in many organs, particularly those of the vascular system, which leads to clinical 'complications' of diabetes. One of the complication that is specific to diabetes is neuropathy. Aim of Work: This study aimed at studying the effect of the disease duration of DM type II (controlled and uncontrolled) on the severity of peripheral neuropathy using the united kingdom screening test (UKST) Scoring System, electrophysiological studies and glycated hemoglobin in under medication type II diabetic patients without current or previous foot ulceration and without any other cause of neuropathy or focal or diffuse radiculopathy. Subjects and methods: This is a case-control study carried out on 60 patients with under medication type II diabetes mellitus (Group A) and 60 healthy controls (Group B). They were recruited from outpatient clinics of Kasr-Alainy, Cairo university hospitals. Results: There was a highly significant reduction in the amplitude and conduction velocities of the group (A) compared to group (B). Also there were highly significant positive correlations between glycated hemoglobin and severity of the signs and symptoms scored by UKST, disease duration, different parameters of nerve conduction studies and MUPs amplitude of different examined muscles. There were also a positive correlation was found between the high amplitude of motor units and the disease duration. Conclusion: According to these study, the UKST, electrophysiological studies and glycated hemoglobin can show the severity of the peripheral neuropathy caused by DM II {u2003}

Issued also as CD