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Biophysical studies on the effect of magnetic field on magneto-liposomes encapsulated with drug / Bassant Moustapha Salah Moustapha ; Supervised Mohamed H. Gaber , Heba M. Fahmy , Nermeen M. Serag

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Bassant Moustapha Salah Moustapha , 2021Description: 59 P. : charts , fascimiles ; 25cmOther title:
  • دراسات بيوفزيائية على تأثير المجال المغناطيسي على الليبوسومات المغناطيسية المحملة بالدواء [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics Summary: Many people are dying from the effect of the drug rather than the disease; that is why the application of the drug has been always a compromise. In the search for effective curing through combining accurate and invasive techniques; aiming to increase the rate of targeted drug release invasively, we designed Magneto-Liposomes (MLs) loaded with Erythromycin drug and subjected it to 5 and 15mT alternating magnetic fields (AMF) at 100 kHz for 30 minutes of exposure.Percentage of Erythromycin released was tested using UPLC-MS/MS method for every hour after exposure until 8 hours, then at 24 hours post-exposure. During exposure, the temperature of the sample was recorded using an IR thermometer.Results showed an elevated temperature of 4 C in the case of exposure to 5mT and of 24 C in the case of exposure to 15mT. In addition, an increase in the percentage of drug release in comparison with the control group.Significantly, upon increasing the intensity of the AMF, the release rate was increased. Exposing Erythromycin-encapsulated ML to AMF accelerated the release rate due to the mechanical actuation of the nanoparticles
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.M.Sc.2021.Ba.B (Browse shelf(Opens below)) Not for loan 01010110084589000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.M.Sc.2021.Ba.B (Browse shelf(Opens below)) 84589.CD Not for loan 01020110084589000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics

Many people are dying from the effect of the drug rather than the disease; that is why the application of the drug has been always a compromise. In the search for effective curing through combining accurate and invasive techniques; aiming to increase the rate of targeted drug release invasively, we designed Magneto-Liposomes (MLs) loaded with Erythromycin drug and subjected it to 5 and 15mT alternating magnetic fields (AMF) at 100 kHz for 30 minutes of exposure.Percentage of Erythromycin released was tested using UPLC-MS/MS method for every hour after exposure until 8 hours, then at 24 hours post-exposure. During exposure, the temperature of the sample was recorded using an IR thermometer.Results showed an elevated temperature of 4 C in the case of exposure to 5mT and of 24 C in the case of exposure to 15mT. In addition, an increase in the percentage of drug release in comparison with the control group.Significantly, upon increasing the intensity of the AMF, the release rate was increased. Exposing Erythromycin-encapsulated ML to AMF accelerated the release rate due to the mechanical actuation of the nanoparticles

Issued also as CD

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