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Evaluation of vascular pattern in mycosis fungoides lesions by dermoscopy and immunohistochemistry / Noha Aly Abdelmonaem ; Supervised Manal A. W. Bosseila , Khadiga Sayed Sayed , Safinaz Salah Eldin Sayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Noha Aly Abdelmonaem , 2014Description: 87 P. : facsimiles ; 25cmOther title:
  • تقييم نمط الأوعية الدموية فى مرض الفطر الفطرانى بواسطة الديرموسكوب و الكيمياء النسيجية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Mycosis fungoides is the most common form of CTCL and accounts for around 60% of new cases. Angiogenesis is a highly ordered process required for the normal remodeling of the primary vascular plexus formed during vasculogenesis. Angiogenesis is involved in the development and progression of pathogenic processes in a variety of disorders and Angiogenesis plays a critical role in solid tumor development and metastasis. Evaluation of vascular pattern in mycosis fungoides and if such pattern would be due to vasodilatation or angiogenesis. Twenty five patients with MF and twenty age and sex matched healthy controls were enrolled in the study. The MF lesions were evaluated by dermoscopy and skin biopsy was taken from all participants. Immunohistochemical (IHC) staining for CD34 was done for the specimen. The total number of blood vessels positive for CD34 (9.1 ± 2.7) and endothelial buds (10.8 ± 4.1) were significantly higher in MF patients than that of controls, (P = 0.000). Dermoscopic evaluation showed that MF exhibts a characteristic dermoscopic pattern, where the dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions followed by the linear pattern
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2014.No.E (Browse shelf(Opens below)) Not for loan 01010110065643000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2014.No.E (Browse shelf(Opens below)) 65643.CD Not for loan 01020110065643000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Mycosis fungoides is the most common form of CTCL and accounts for around 60% of new cases. Angiogenesis is a highly ordered process required for the normal remodeling of the primary vascular plexus formed during vasculogenesis. Angiogenesis is involved in the development and progression of pathogenic processes in a variety of disorders and Angiogenesis plays a critical role in solid tumor development and metastasis. Evaluation of vascular pattern in mycosis fungoides and if such pattern would be due to vasodilatation or angiogenesis. Twenty five patients with MF and twenty age and sex matched healthy controls were enrolled in the study. The MF lesions were evaluated by dermoscopy and skin biopsy was taken from all participants. Immunohistochemical (IHC) staining for CD34 was done for the specimen. The total number of blood vessels positive for CD34 (9.1 ± 2.7) and endothelial buds (10.8 ± 4.1) were significantly higher in MF patients than that of controls, (P = 0.000). Dermoscopic evaluation showed that MF exhibts a characteristic dermoscopic pattern, where the dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions followed by the linear pattern

Issued also as CD

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