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Evaluation of circulating biomarkers (miRNAs) and their correlation with neuroimaging and neurophysiological studies (EEG) in epileptic patients / Nesma Mounir Abdalgaber Abdalsalam ; Supervised Mervat Moustafa Mahmoud , Noha Taha Mostafa Abokrysha , Dalia Mohamed Labib Abdalazeem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nesma Mounir Abdalgaber Abdalsalam , 2019Description: 176 P. : charts , facsimiles ; 25cmOther title:
  • بالدم وعلاقتها بالرنين المغناطيسي علي المخ ورسم المخ في مرضي الصرع (miRNAs) تقييم مستوي المؤشرات الحيوية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry Summary: Background: Epilepsy is a chronic neurological disorder. Diagnosis is based on clinical examination, electroencephalogram (EEG), and neuroimaging. A suitable biomarker for epilepsy diagnosis is under research .MicroRNAs are non-coding RNA related to epileptogenesis and dysregulated in epileptic patients, their potential use as a biomarker of epilepsy is still under research. Aim of the work: to investigate the expression level of miR 106b,146a and 194-5p in epileptic patients compared to control subjects in correlation to clinical characteristics. Methodology The expression of three epilepsy-associated miRNAs (miR-106b, miR-146a,and miR-194-5p) was measured by quantitative RT-PCR, using SYBR Green Master Mix fluorescence with Specific primers in the serum of 30 epilepsy patients divided into 2 subgroups (idiopathic generalized and idiopathic focal epilepsies) and 20 control populations. Results: Serum miR-106b, miR194-5p were significantly increased in generalized epilepsy patients compared with control, miR 194-5P was significantly down regulated in focal epilepsy group. In addition, serum miR 194 -5p was significantly correlated to disease duration in group 1, the three microRNA were significantly correlated to each other
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.21.Ph.D.2019.Ne.E (Browse shelf(Opens below)) Not for loan 01010110079085000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.21.Ph.D.2019.Ne.E (Browse shelf(Opens below)) 79085.CD Not for loan 01020110079085000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Background: Epilepsy is a chronic neurological disorder. Diagnosis is based on clinical examination, electroencephalogram (EEG), and neuroimaging. A suitable biomarker for epilepsy diagnosis is under research .MicroRNAs are non-coding RNA related to epileptogenesis and dysregulated in epileptic patients, their potential use as a biomarker of epilepsy is still under research. Aim of the work: to investigate the expression level of miR 106b,146a and 194-5p in epileptic patients compared to control subjects in correlation to clinical characteristics. Methodology The expression of three epilepsy-associated miRNAs (miR-106b, miR-146a,and miR-194-5p) was measured by quantitative RT-PCR, using SYBR Green Master Mix fluorescence with Specific primers in the serum of 30 epilepsy patients divided into 2 subgroups (idiopathic generalized and idiopathic focal epilepsies) and 20 control populations. Results: Serum miR-106b, miR194-5p were significantly increased in generalized epilepsy patients compared with control, miR 194-5P was significantly down regulated in focal epilepsy group. In addition, serum miR 194 -5p was significantly correlated to disease duration in group 1, the three microRNA were significantly correlated to each other

Issued also as CD

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