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Detection of high level aminoglycoside resistance and reduced susceptibility to vancomycin among enterococcal clinical isolates / Pakinam Reda Hamzawy ; Supervised Hala Mohamed Safouh , Manal Saad Diab , Alaa Mohamed Reda Awad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Pakinam Reda Hamzawy , 2015Description: 123 P. : charts , facsimiles ; 25cmOther title:
  • الكشف عن مقاومة بكتيريا ا{uئإئ٩}نتيروكوكاى للأمينوجليكوزيد العالى التركيز و انخفاض فاعلية الفانكوميسين من العينات ا{uئإئ٩}كلينيكية المعزولة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology Summary: Enterococci are Gram positive bacteria that have become an important clinical pathogen and are considered as the second leading cause of healthcare - associated bacteremia with E. faecalis and E. faecium representing the two most common enterococcal species comprising about 5 to 15% of cases of infectious endocarditis, as well as UTIs followed by intra abdominal, pelvic and soft tissue infections. Enterococci have the capacity to acquire resistance to antibiotics including high level resistance to aminoglycosides (HLAR) and glycopeptides including VRE. This evolution of anti microbial resistance in enterococci poses enormous challenges for treatment especially when faced with patients with severe infections. Antibiotics such as linezolid, daptomycin and tigecycline may offer alternative solution for treatment of VRE infections. In the current study we aimed to identify the enterococcal species, determine their antibiotic sensitivity, including HLAR, low susceptibility to vancomycin and detect Ý- lactamase production. In addition we aimed to evaluate therapeutic options for MDR enterococci namely linezolid and tigecycline. Fifty enterococcal species were isolated, E. faecalis 38 / 50, 76% was predominant over E. faecium 12 / 50, 24%
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.M.Sc.2015.Pa.D (Browse shelf(Opens below)) Not for loan 01010110068219000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.M.Sc.2015.Pa.D (Browse shelf(Opens below)) 68219.CD Not for loan 01020110068219000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology

Enterococci are Gram positive bacteria that have become an important clinical pathogen and are considered as the second leading cause of healthcare - associated bacteremia with E. faecalis and E. faecium representing the two most common enterococcal species comprising about 5 to 15% of cases of infectious endocarditis, as well as UTIs followed by intra abdominal, pelvic and soft tissue infections. Enterococci have the capacity to acquire resistance to antibiotics including high level resistance to aminoglycosides (HLAR) and glycopeptides including VRE. This evolution of anti microbial resistance in enterococci poses enormous challenges for treatment especially when faced with patients with severe infections. Antibiotics such as linezolid, daptomycin and tigecycline may offer alternative solution for treatment of VRE infections. In the current study we aimed to identify the enterococcal species, determine their antibiotic sensitivity, including HLAR, low susceptibility to vancomycin and detect Ý- lactamase production. In addition we aimed to evaluate therapeutic options for MDR enterococci namely linezolid and tigecycline. Fifty enterococcal species were isolated, E. faecalis 38 / 50, 76% was predominant over E. faecium 12 / 50, 24%

Issued also as CD

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