Effects of liraglutide and sulforaphane on peripheral neuropathy in diabetes induced in rats / Passant Elwy Ibrahim Moustafa ; Supervised Hala F. Zaki , Osama A. Elshabrawy , Noha F. Abdelkader

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Diabetic peripheral neuropathy is counted as one of the most common microvascular complications that happens with both type1 and type 2 diabetes mellitus. Diabetic peripheral neuropathy has a marked negative effect on patients{u2019} quality of life as it starts with loss of limbs{u2019} sensation and may result in lower limb amputation. This study aimed at exploring the effect of liraglutide and sulforaphane on diabetes-induced peripheral neuropathy in rats. Experimental diabetes mellitus was induced by single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg). Eighty-four rats were allocated into seven groups. Three groups were given saline and tween 80, liraglutide (0.8 mg/kg, s.c.) or sulforaphane (1 mg/kg, p.o.). Four diabetic groups were either untreated or treated with liraglutide (0.8 mg/kg, s.c.), sulforaphane (1 mg/kg, p.o.) or pregabalin (10 mg/kg, i.p.). After two weeks of treatment, behavioral, biochemical, histopathological and immunohistochemical investigations were carried out. Treatment with liraglutide or sulforaphane restored animals{u2019} body weight, decreased blood glucose and glycated hemoglobin levels and increased serum insulin level

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