A pharmaceutical study on gastroretentive pulsatile delivery systems for certain chronological drugs / Rasha Salah Eldin Mahmoud Elbatanony ; Supervised Seham Abdelkhalek Elkheshen , Mina Ibrahim Tadros

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Rasha Salah Eldin Mahmoud Elbatanony

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Material type: Text

TextLanguage: English Publication details: Cairo : Rasha Salah Eldin Mahmoud Elbatanony , 2016Description: 265 P. : facsimiles ; 25cmOther title:

درا{uئإآ٣}{uئإ٩٤} {uئإآآ}{uئإئ٤}{uئإءء}{uئإؤئ}{uئإئ٤}{uئإ٩٤} {uئإأآ}{uئإإ٠}{uئإئ٢} أ{uئإإ٧}{uئإأ٨}{uئإإ٤}{uئإ٩٤} {uئإء٣}{uئإؤ٤}{uئإأ٦} {uئإإ٣}{uئإأأ}{uئإءء}ى {uئإإ٧}{uئإ٨إ}{uئإ٩١}{uئإأ٠}{uئإإء} {uئإؤئ}{uئإإ٨}{uئإؤ٨}{uئإؤإ} {uئإ٩١}{uئإأأ}{uئإآإ} ا{uئإؤئ}{uئإأأ}{uئإؤ٨}{uئإ٨إ}{uئإؤ٧}{uئإئ٤}{uئإءإ} ا{uئإؤئ}{uئإإ٤}{uئإءإ}{uئإ٩٧}{uئإ٩٢}{uئإإء} ز{uئإإ٣}{uئإإ٨}{uئإئ٤}{uئإ٨إ} [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: A combination of gastroretentive and pulsatile principles offers an advantage that the system can achieve long residence time in the stomach, sufficient for delivering an adequate amount of drug at the right time, particularly in diseases requiring medication during sleeping and awakening. Developed press coated tablet was found to be suitable for gastroretentive pulsatile delivery of freely soluble drugs after reasonable lag time but not suitable for sparingly soluble drugs and for lesser extent for the practically insoluble drugs. The best achieved formula was found to be containing propranolol hydrochloride (freely soluble drug), ludipress® as core tablet filler, coat polymer blend (methocel® K4M / ethylcellulose 100) with polymer to polymer ratio (60 / 40) and core to coat ratio (1:2). Developed core in cup tablet was found to be suitable for gastroretentive pulsatile delivery of sparingly soluble drugs after reasonable lag time but not suitable for freely soluble drugs and for lesser extent for the practically insoluble drugs

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.08.Ph.D.2016.Ra.P (Browse shelf(Opens below))		Not for loan		01010110070781000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.08.Ph.D.2016.Ra.P (Browse shelf(Opens below))	70781.CD	Not for loan		01020110070781000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

A combination of gastroretentive and pulsatile principles offers an advantage that the system can achieve long residence time in the stomach, sufficient for delivering an adequate amount of drug at the right time, particularly in diseases requiring medication during sleeping and awakening. Developed press coated tablet was found to be suitable for gastroretentive pulsatile delivery of freely soluble drugs after reasonable lag time but not suitable for sparingly soluble drugs and for lesser extent for the practically insoluble drugs. The best achieved formula was found to be containing propranolol hydrochloride (freely soluble drug), ludipress® as core tablet filler, coat polymer blend (methocel® K4M / ethylcellulose 100) with polymer to polymer ratio (60 / 40) and core to coat ratio (1:2). Developed core in cup tablet was found to be suitable for gastroretentive pulsatile delivery of sparingly soluble drugs after reasonable lag time but not suitable for freely soluble drugs and for lesser extent for the practically insoluble drugs

Issued also as CD

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