Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology

Cancer has a profound effect on the host{u2019}s metabolism, resulting in alteration of the serum concentration of amino acids. The aim of the study was to detect specific serum amino acid profiles in patients with breast and liver malignancies as well as their high risk groups that may represent a new biomarker for an early detection and diagnosis of malignancies. We analyzed serum level of 16 amino acids by amino acid analyzer technique in patients with breast cancer, their high risk group, liver cancer, their high risk group and healthy normal group. The results obtained revealed that patients with breast cancer had a significant elevation in all studied amino acids except alanine. Also tyrosine level was the amino acid that showed a significant increase in serum of both breast cancer and their high risk group. In case of liver cancer a significant elevation was observed in 6 amino acids. Also methionine was the amino acid that showed a significant elevation in both patients with liver cancer and their high risk group. Serum amino acids profiling with special reference to tyrosine and methionine could be useful biomarker in enhanced detection of breast and liver malignancies

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