Assessment of Pentraxin (3) level in Egyptian children with Familial Mediterranean Fever / Sahar Ismail Hatoum ; Supervised Huda Marzouk Mohamed , Mervat Mamdouh khorsheid , Sarah Ali Zenhom Mohamed

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background : Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of fever accompanied by peritonitis, pleuritis, arthritis, and erysipelas-like erythema.Objective: to assess the serum PTX3 levels in attack-free period FMF children as a marker of subclinical inflammation.Methods: This study was conducted on Fifty one Egyptian children diagnosed with FMF according to the new FMF criteria (Yalçinkaya et al., 2009). Patients in attack-free period. They are being followed up in Pediatric Rheumatology outpatient clinic of Abo-Elreesh hospital, Cairo University. Together with thirty healthy children, age and sex-matched, coming for regular follow up at Abo-Elreesh Pediatric General clinic. A blood sample was withdrawn under complete aseptic conditions. Pentraxin 3 level was determined by ELISA.Results: Patients were found to have a significant higher plasma pentraxin 3 level (median is 0.57 ng/dl) than healthy control group (median is 0.43) with (p value= 0.004) especially in homozygous patients. PTX3 levels in our FMF patients showed significant negative correlation with the disease duration with p value = 0.001, duration of attacks with P value = 0.018, duration of colchicine therapy with P value =0.003 and VAS before colchicine with P value = 0.007.Conclusion: our study showed high Pentraxin 3 level in patients of FMF during attack-free periods compared to healthy children. That shows the prescence of ongoing subclinical inflammation in especially in homozygous patients

Issued also as CD