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Evaluation of ROCK2 Level in Egyptian Patients with Multiple Sclerosis: Relation with Certain Circulating MicroRNAs during Disease Progression / Samar Hussein Ibrahim ; Supervised Amira A. Shaheen , Maha M. Elsawalhi , Mae M. Selim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samar Hussein Ibrahim , 2020Description: 105 P. : charts , facsmilies ; 25cmOther title:
  • العلاقة مع بعض الأحماض النووية الريبوزية الصغيرة أثناء تطور المرض : تقييم مستوى الروك-2 فى المرضى المصريين المصابين بالتصلب المُتعدِد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Multiple Sclerosis (MS) is an autoimmune disease that attacks the CNS. The majority of patients initially present with a relapsing remitting course (RRMS), where at some point, most RRMS patients progress into secondary progressive form (SPMS). The diversity of MS courses is not well correlated with the current biomarkers. Therefore, this study aimed to assess ROCK2 concentration and the expression profiles of miR-300 and miR-450b-5p in Egyptian MS patients and evaluate their relation to clinical parameters. Additionally, their potential use as novel prognostic biomarkers for MS was also analyzed. ROCK2 level and miRNAs expression were evaluated in the serum of 74 MS patients (39 RRMS and 35 SPMS) and 10 healthy controls (HCs) using ELISA and qRT-PCR, respectively
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2020.Sa.E (Browse shelf(Opens below)) Not for loan 01010110081993000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2020.Sa.E (Browse shelf(Opens below)) 81993.CD Not for loan 01020110081993000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Multiple Sclerosis (MS) is an autoimmune disease that attacks the CNS. The majority of patients initially present with a relapsing remitting course (RRMS), where at some point, most RRMS patients progress into secondary progressive form (SPMS). The diversity of MS courses is not well correlated with the current biomarkers. Therefore, this study aimed to assess ROCK2 concentration and the expression profiles of miR-300 and miR-450b-5p in Egyptian MS patients and evaluate their relation to clinical parameters. Additionally, their potential use as novel prognostic biomarkers for MS was also analyzed. ROCK2 level and miRNAs expression were evaluated in the serum of 74 MS patients (39 RRMS and 35 SPMS) and 10 healthy controls (HCs) using ELISA and qRT-PCR, respectively

Issued also as CD

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