Tissue doppler imaging to detect subtle myocardial affection in asymptomatic patients with nephrotic syndrome / Samar Younis Taha Mohamed ; Supervised Mervat Ahmed Haroun , Amr Mohamed Salem , Antoine Fakhry Abdelmassih

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Nephrotic syndrome (NS) is a clinical condition characterized by massive proteinuria, hypoalbuminemia, hypercholesterolemia, and generalized edema. Nephrotic syndrome (NS) is associated with increased cardiovascular morbidity and mortality. Their appearance is related to excessive loss of albumin in urine, oxidative stress, or to steroid therapy, all of these can result in endothelial dysfunction, which is now emerging as the most important component in the thrombotic process.. Early recognition and appropriate therapy of diastolic dysfunction are advisable to prevent further progression to diastolic heart failure and death. Newer echocardiographic methods like Tissue Doppler imaging and 2D speckle tracking analysis allow assessment of myocardial deformation as new sensitive marker for detection of subtle myocardial dysfunction. Objectives: The aim of this study was to improve the quality of life and life expectancy of nephrotic syndrome patients by improving the diagnostic tools of early detection of subtle myocardial dysfunction in nephrotic syndrome patients. Patients and methods: Our study was a Case-Control Cross-sectional study conducted at Children Hospital, Cairo University during the period from December 2017 to August 2018, included 70 children, 40 patients with nephrotic syndrome and 30 apparently healthy children randomly chosen from children coming to general clinic in the children hospital as controls. Written approval to participate in the study was taken

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