Assessment the effect of laser biostimulation and mesenchymal stem cells on the rate of orthodontic relapse in rats / Samer Salim Othman Ayob Alnua,amy ; Supervised Ali Mohamed Saafan , Amr Ragab Elbeialy , Mohammad Mahmoud Farhan

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Samer Salim Othman Ayob Alnua,amy

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TextLanguage: English Publication details: Cairo : Samer Salim Othman Ayob Alnua,amy , 2021Description: 220 P. : charts , facsimiles ; 25cmOther title:

تقييم تأثير التحفيز لليزر والخلايا الجذعية الوسيطة على معدل الانتكاس التقويمى فى الفئران [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser in Applications Oral Surgery Dentistry Summary: Background: Relapse after orthodontic tooth development (OTM) happens through the rebuilding of the trans-formed periodontal ligament (PDL), this rebuilding process involves the extracellular matrix (ECM). Low level laser therapy (LLLT) biostimulation might enhance bone redesigning, with expanded collagen union, bone development and mineralization, cell expansion and separation, and angiogenesis. it was hypothesized that LLLT may inhibit relapse due to accelerated bone regeneratio. Mesenchymal stem cells (MSCs) might promote tissue formation through their own differentiation or by ctivating endogenous progenitor cells when exposed to an inflamed microenvironment. Aim of the study : The aim of the presented study was to investigate the effect of low level laser therapy and the bone marrow mesenchymal stem cells on the rate of orthodontic relapse in rats. Methods: Sixty males, 8 weeks old, Wistar rats with their maxillary central incisors had undergone an orthodontic distal movement for 2 weeks. The distally moved central incisors were temporarily fixed using a wire-resin splint retainer for one week. After retainer removal the rats were subdivided to 4 equal groups: Group (1) (C) without any intervention, to act as the baseline control group. Group (2) (L) low level laser therapy (LLLT) was used to irradiate the mesial aspect of the root of maxillary central incisors. Group (3) (SC25) MSCs group, in which (50000) MSCs were applied on the mesial aspect of the root of maxillary central incisors. Group (4) (SC50) in which (100000) MSCs were applied on the mesial aspect of the root of maxillary central incisors. Group (5) (LSC25) Combined group, with both BMMSCs and LLLT application

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.24.04.Ph.D.2021.Sa.A (Browse shelf(Opens below))		Not for loan		01010110084659000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.24.04.Ph.D.2021.Sa.A (Browse shelf(Opens below))	84659.CD	Not for loan		01020110084659000

Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser in Applications Oral Surgery Dentistry

Background: Relapse after orthodontic tooth development (OTM) happens through the rebuilding of the trans-formed periodontal ligament (PDL), this rebuilding process involves the extracellular matrix (ECM). Low level laser therapy (LLLT) biostimulation might enhance bone redesigning, with expanded collagen union, bone development and mineralization, cell expansion and separation, and angiogenesis. it was hypothesized that LLLT may inhibit relapse due to accelerated bone regeneratio. Mesenchymal stem cells (MSCs) might promote tissue formation through their own differentiation or by ctivating endogenous progenitor cells when exposed to an inflamed microenvironment. Aim of the study : The aim of the presented study was to investigate the effect of low level laser therapy and the bone marrow mesenchymal stem cells on the rate of orthodontic relapse in rats. Methods: Sixty males, 8 weeks old, Wistar rats with their maxillary central incisors had undergone an orthodontic distal movement for 2 weeks. The distally moved central incisors were temporarily fixed using a wire-resin splint retainer for one week. After retainer removal the rats were subdivided to 4 equal groups: Group (1) (C) without any intervention, to act as the baseline control group. Group (2) (L) low level laser therapy (LLLT) was used to irradiate the mesial aspect of the root of maxillary central incisors. Group (3) (SC25) MSCs group, in which (50000) MSCs were applied on the mesial aspect of the root of maxillary central incisors. Group (4) (SC50) in which (100000) MSCs were applied on the mesial aspect of the root of maxillary central incisors. Group (5) (LSC25) Combined group, with both BMMSCs and LLLT application

Issued also as CD

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