Evaluation of the protective effect of vitamin E on molecular and histopathological changes caused by pregabalin toxicity on brain and reproductive system of adult albino rats / Sarah Hamed Nasreldin Taha Mohamed ; Supervised Hala Saied Zaghloul , Abla Abdelrahman Ali , Laila Ahmed Rashed

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine and Clinical Toxicology

Introduction: Pregabalin was synthesized as an antiepileptic in 1990.It acts through increasing neuronal GABA levels by selectively binding to the alpha 2 delta subunits of voltage-gated calcium channels and inhibiting the release of excitatory neurotransmitters. Its abuse liability was thought to be minimal until 2004 when case reports raised concern about using it as recreational drug. Aim: To study the toxic effects of pregabalin on brain and reproductive organs and to clarify the possible causing mechanisms of these hazards and finally, to assess the therapeutic effects of vitamin E against these hazards in adult albino rats that were exposed to pregabalin for 90 consecutive days. Materials and Methods: 140 rats were divided into 12 groups (6 groups male and 6 groups female). Each group contains 10 rats except group 1M in males and group 1F in females which contain 20 rats each and divided into two subgroups with 10 rats in each subgroup. Male groups: Group 1M(A) received distilled water, Group 1M(B) received corn oil, Group 2M received vit E in corn oil (100mg/kg), Group 3M received pregabalin in distilled water (150mg/kg), Group 4M received pregabalin in distilled water (300mg/kg), Group 5M received pregabalin in distilled water (150mg/kg) + vit E in corn oil (100mg/kg), and Group 6M received pregabalin in distilled water (300mg/kg) + vit E in corn oil (100mg/kg) for 90 days

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