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Renal histopathological changes and clinical characteristics of nephropathy associated with antiphospholipid antibodies in systemic lupus erythematosus patients / Ahmed Ameen Elmaghraby ; Supervised Hanan Ahmed Kotb , Abeer Nabil Mokbel , Sawsan Abdelmonaem Fadda

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Ameen Elmaghraby , 2014Description: 249 P. : charts , facsimiles ; 25cmOther title:
  • التغيرات الباثولوجيه فى الكلى و السمات الأكلينيكيه لأصابة الكلى المرتبطه بالأجسام المضاده للدهون الفسفوريه فى مرضى الذئبة الحمراء [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation Summary: The aim of the study is to evaluate the renal histopathological changes and clinical characteristics of nephropathy associated with antiphospholipid antibodies in systemic lupus erythematosus patients, compared to nephropathy in the absence of antiphospholipid antibodies. Results: the existence of APSN was strongly associated with aPLs positivity (P=0.016). The prevalence of APSN was 34% among lupus nephritis patients; it was detected in 52% and 16% in aPLs positive and aPLs negative patients respectively. APSN was significantly associated with older age (P=0.032). No statistical significant difference between patients with APSN and those without APSN in terms of renal functions, proteiuria, urine analysis findings, systemic hypertension and APS manifestations (P>0.05 for all). However, acute APSN (thrombotic microangiopathy; TMA), but not chronic APSN, was strongly associated with renal dysfunction and systemic hypertension (P<0.05 for all). Overall APSN, acute APSN (TMA) and chronic APSN were strongly Abstract associated with LAC positivity and titer (P<0.05 for all), but neither aCLs IgG nad IgM nor anti-Ý2GPI IgG and IgM. The detection of APSN was significantly associated with higher chronicity index score, more interstitial fibrosis and tubular atrophy (P<0.05 for all)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Ah.R (Browse shelf(Opens below)) Not for loan 01010110065303000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Ah.R (Browse shelf(Opens below)) 65303.CD Not for loan 01020110065303000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation

The aim of the study is to evaluate the renal histopathological changes and clinical characteristics of nephropathy associated with antiphospholipid antibodies in systemic lupus erythematosus patients, compared to nephropathy in the absence of antiphospholipid antibodies. Results: the existence of APSN was strongly associated with aPLs positivity (P=0.016). The prevalence of APSN was 34% among lupus nephritis patients; it was detected in 52% and 16% in aPLs positive and aPLs negative patients respectively. APSN was significantly associated with older age (P=0.032). No statistical significant difference between patients with APSN and those without APSN in terms of renal functions, proteiuria, urine analysis findings, systemic hypertension and APS manifestations (P>0.05 for all). However, acute APSN (thrombotic microangiopathy; TMA), but not chronic APSN, was strongly associated with renal dysfunction and systemic hypertension (P<0.05 for all). Overall APSN, acute APSN (TMA) and chronic APSN were strongly Abstract associated with LAC positivity and titer (P<0.05 for all), but neither aCLs IgG nad IgM nor anti-Ý2GPI IgG and IgM. The detection of APSN was significantly associated with higher chronicity index score, more interstitial fibrosis and tubular atrophy (P<0.05 for all)

Issued also as CD

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