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Genetic and radiological biomarkers of cognitive impairment in parkinson's disease / Mona Hussein Tawfek Saber ; Supervised Omar Amen Alserafy , Rasha Hassan Soliman , Shahera Morsi Elshafie

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mona Hussein Tawfek Saber , 2014Description: 230 P. : charts , facsimiles ; 25cmOther title:
  • المؤشرات الجينية و الاشعاعية لتدهور القدرات المعرفية فى مرض الشلل الرعاش [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery Summary: Cognitive impairment in parkinson's disease (PD) has been clearly reported in the medical literature. The exact pattern of this impairment and its biomarkers are still subjects of considerable controversy. To explore the cognitive profile of patients with PD, correlate such profile with the macro and microstructural changes in the brain, evaluate the role of P300 in assessment of cognitive function in PD, and study the role of the genetic factor in the development of cognitive impairment in PD. The study was conducted on 40 patients with PD and 20 controls. Selected PD patients were submitted to evaluation of motor symptoms and psychiatric manifestations using H and Y staging and UPDRS, assessment of cognitive function using PD - cognitive rating scale (PD - CRS), assessment of global brain atrophy using MRI, assessment of microstructural changes in BG, thalamus, hippocampus and prefrontal white matter using diffusion tensor imaging, measurement of P300 latency, and genotyping for GBA (L444P) mutation and BDNF (Val66Met) polymorphism
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.Ph.D.2014.Mo.G (Browse shelf(Opens below)) Not for loan 01010110065215000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.20.Ph.D.2014.Mo.G (Browse shelf(Opens below)) 65215.CD Not for loan 01020110065215000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery

Cognitive impairment in parkinson's disease (PD) has been clearly reported in the medical literature. The exact pattern of this impairment and its biomarkers are still subjects of considerable controversy. To explore the cognitive profile of patients with PD, correlate such profile with the macro and microstructural changes in the brain, evaluate the role of P300 in assessment of cognitive function in PD, and study the role of the genetic factor in the development of cognitive impairment in PD. The study was conducted on 40 patients with PD and 20 controls. Selected PD patients were submitted to evaluation of motor symptoms and psychiatric manifestations using H and Y staging and UPDRS, assessment of cognitive function using PD - cognitive rating scale (PD - CRS), assessment of global brain atrophy using MRI, assessment of microstructural changes in BG, thalamus, hippocampus and prefrontal white matter using diffusion tensor imaging, measurement of P300 latency, and genotyping for GBA (L444P) mutation and BDNF (Val66Met) polymorphism

Issued also as CD

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