Analytical study of some drugs containing cyclic nitrogen / Sherine Salah Eldin Shebl Diab ; Supervised Azza Aziz Moustafa Mohamed , Nesrin Khamis Ramadan Selim , Hanan Abdelmonem Ahmed Merey

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

Several drugs with different pharmacological actions share the cyclic nitrogen nucleus, including antihypertensive and antidiabetic drugs, which were the main focus in our study. During the past few years, most of medications introduced to the market as 2polypill3 tablets or capsules that combine multiple active pharmaceutical ingredients, especially those used for treatment of hypertension or diabetes mellitus. Under these circumstances, there are many advantages to patients and doctors in providing fixed combinations since it could help patients to adhere to recommended regimens, and overcome the risk of unexpected drug interaction. The drug mixtures under study have been recently approved by the FDA to be marketed in their combined dosage form. The combinations of; (Amlodipine besylate - Olmesartan medoxomil - Hydrochlorothiazide), (Lercanicdipine HCl - Enalapril maleate) and (Telmisartan - Amlodipine besylate) are prescribed as single dose polypill tablets for the clinical treatment of hypertension, while the combination (Saxagliptin HCl - Metformin HCl) is recommended for diabetes mellitus treatment. Various analytical techniques were used for the simultaneous analysis of these drug mixtures

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