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Influence of ÝS-globin haplotype on stroke risk as detected by TCD among a cohort of Egyptian children with sickle cell disease / Shireen Ahmed Hefny Mohammed ; Supervised Heba Hassan AbouElew , Ilham Youssry , Rania Ahmed Zayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shireen Ahmed Hefny Mohammed , 2016Description: 143 P. : facsimiles ; 25cmOther title:
  • تأثير النمط الجينى لبيتا إس على خطر الإصابة بالسكتة الدماغية فى مجموعة من الأطفال المصريين المصابين بداء فقر الدم المنجلى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cliinical and Chemical Pathology Summary: Sickle cell disease (SCD) is an inherited disease of beta globin gene. The ÝS haplotypes are senegal, benin, bantu, cameroon, Arab-Indian and atypical haplotypes. Stroke is a catastrophic complication of SCD and is one of the leading causes of death in both adults and children. In light of paucity of studies on ÝS haplotypes in Egypt, the aim of the present study was to determine ÝS haplotypes in 52 children with SCD and evaluate their influence on clinical and hematological features of SCD and their possible prognostic impact on the development of stroke. Benin / benin was the most prevalent haplotype detected in 50% followed by Benin/Bantu in 30.8% of studied patients. Patients with benin / benin haplotype have higher stroke risk and fairly lower HbF% than non Benin/Benin although statistically insignificant. No statistically significant difference was observed regarding other clinical or laboratory parameters between different ÝS haplotypes. Regular blood transfusion was statistically significantly associated with low stroke risk (p<0.001). This study provides a relevant contribution to our understanding of the anthropological and historical background of the population in Egypt. Other genetic, epigenetic and environmental factors may modulate stroke susceptibility in SCD
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2016.Sh.I (Browse shelf(Opens below)) Not for loan 01010110071438000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2016.Sh.I (Browse shelf(Opens below)) 71438.CD Not for loan 01020110071438000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cliinical and Chemical Pathology

Sickle cell disease (SCD) is an inherited disease of beta globin gene. The ÝS haplotypes are senegal, benin, bantu, cameroon, Arab-Indian and atypical haplotypes. Stroke is a catastrophic complication of SCD and is one of the leading causes of death in both adults and children. In light of paucity of studies on ÝS haplotypes in Egypt, the aim of the present study was to determine ÝS haplotypes in 52 children with SCD and evaluate their influence on clinical and hematological features of SCD and their possible prognostic impact on the development of stroke. Benin / benin was the most prevalent haplotype detected in 50% followed by Benin/Bantu in 30.8% of studied patients. Patients with benin / benin haplotype have higher stroke risk and fairly lower HbF% than non Benin/Benin although statistically insignificant. No statistically significant difference was observed regarding other clinical or laboratory parameters between different ÝS haplotypes. Regular blood transfusion was statistically significantly associated with low stroke risk (p<0.001). This study provides a relevant contribution to our understanding of the anthropological and historical background of the population in Egypt. Other genetic, epigenetic and environmental factors may modulate stroke susceptibility in SCD

Issued also as CD

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