Level of some adipokines in obese type 2 diabetic Egyptian patients with coronary artery stenosis / Rania Farag Ahmed Eltelbany ; Supervised Tarek M. K. Motawi , Soliman G. Mahdy , Maha M. Elsawalhi

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Cardiovascular diseases (CVD) have been considered the leading cause of death in diabetic population. Obesity is a growing serious problem that has been linked with CVD and diabetes via a variety of adipokines. The aim of this study was to evaluate the levels of chemerin, apelin, vaspin and omentin-1 in obese T2DM Egyptian patients with coronary artery stenosis (CAS) and to analyze the relationship between these four adipokines and the biochemical characteristics of those patients. Additionally, the potential usefulness of these adipokines as non-invasive diagnostic biomarkers was also assessed for CAS. Ninety patients with CAS and 30 healthy controls were enrolled in the study. Patient with CAS were further classified into two groups: CAD I included 45 (non-obese and non-diabetic patients with CAS) and CAD II included 45 (obese and diabetic patient with CAS). Patients in CAD I and CAD II groups exhibited significantly higher levels of both chemerin and apelin compared to healthy controls, with more significant increase in CAD II than CAD I group. On the other hand, serum levels of both vaspin and omentin-1 were significantly lower in CAD I and CAD II patients compared to normal subjects with more significant decrease in CAD II than CAD I group. Additionally, chemerin, apelin, vaspin and omentin-1 levels were individually correlated with certain biochemical variables as well as with each other. Moreover, our data showed the ability of chemerin and vaspin levels to differentiate obese T2DM patients with CAS from both controls and non-obese non-diabetic patients with CAS Alteration of chemerin, apelin, vaspin and omentin-1 levels may play a crucial role in the pathogenesis of CAS in obese T2DM Egyptian patients

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