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Development and validation of analytical methods for determination of some drugs affecting CNS / Rowayda Mohamed Fouad Ali ; Supervised Azza Aziz Mohamed Moustafa , Nesrin Khamis Ramadan Selim , Taghreed Abdelfattah Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rowayda Mohamed Fouad Ali , 2018Description: 271 P. : charts , facsimiles ; 25cmOther title:
  • تطوير وصلاحية طرق تحليلية لتحليل بعض العقاقير المؤثرة على الجهاز العصبي [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: The scientific work in this thesis is concerned with the analysis of some drugs affecting CNS namely Asenapine maleate (AS) and Cyclobenzaprine hydrochloride (CB). The aim of the present work is the development of feasible, accurate, precise, sensitive and specific analytical methods for the determination of the mentioned drugs in presence of their degradation products and the adaptation of these methods to the quantitative determination of their pharmaceutical dosage forms.The quantification of the chosen drugs has been carried out by adopting a variety of analytical methods then the developed methods were validated according to ICH guidelines. The methods used for their determination were: spectrophotometric methods (second derivative, third derivative, ratio difference, derivative ratio, dual wavelength and isoabsorptive point), spectrofluorimetric, HPLC, TLC-separation with densitometric analysis, potentiometric methods (ion selective electrode using carbon paste and PVC membrane) and conductometric methods. The experimental conditions of each of the proposed methods were optimized and described in details
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2018.Ro.D (Browse shelf(Opens below)) Not for loan 01010110076561000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2018.Ro.D (Browse shelf(Opens below)) 76561.CD Not for loan 01020110076561000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

The scientific work in this thesis is concerned with the analysis of some drugs affecting CNS namely Asenapine maleate (AS) and Cyclobenzaprine hydrochloride (CB). The aim of the present work is the development of feasible, accurate, precise, sensitive and specific analytical methods for the determination of the mentioned drugs in presence of their degradation products and the adaptation of these methods to the quantitative determination of their pharmaceutical dosage forms.The quantification of the chosen drugs has been carried out by adopting a variety of analytical methods then the developed methods were validated according to ICH guidelines. The methods used for their determination were: spectrophotometric methods (second derivative, third derivative, ratio difference, derivative ratio, dual wavelength and isoabsorptive point), spectrofluorimetric, HPLC, TLC-separation with densitometric analysis, potentiometric methods (ion selective electrode using carbon paste and PVC membrane) and conductometric methods. The experimental conditions of each of the proposed methods were optimized and described in details

Issued also as CD

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