Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Egypt considered a highly endemic country for H. pylori, it{u2019}s associated with gastritis, peptic ulcer disease and gastric cancer. Stool antigen test considered as a non-invasive reliable test. Salivary PCR considered is a New modality for diagnosis of H. pylri. To evaluate the validity of salivary PCR test in diagnosis of H. pylori This study included 50 patients attendants of gastrointestinal endoscopy unit Faculty of medicine, Cairo university. They all proved histologically to have H.pylori induced gastric and/ or duodenal pathology. All underwent stool antigen test and salivary samples for H. pylori PCR. Prevalence of H. pylori in symptomatizing Egyptian patients was 62.5%. Patients were middle aged (mean age was 42.0 ± 11.6 years old), and comparable gender presentation (54% females versus 46% males). The commonest endoscopic findings were gastric affection (90%), and duodenal affection (44%), third of cases (34%) showed definite ulcer lesions. Interestingly, none of the patients had either complicated peptic ulcer disease, nor malignant growth. Sensitivity of SAT was 82%, and was significantly related to epigastric pain, the commones complaint, but was not related to the endoscopic finding

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