Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology

Background: Chemerin is a newly discovered adipokine which has been found closely associated with obesity, metabolic syndrome, and inflammatory status. However, it remains un»clear whether chemerin is involved in patients with cardiovascular disease. Objective: The aim of the study was to examine whether serum chemerin levels are associated with the severity of coronary artery disease (CAD) in obese Egyptian patients. Material and methods: The study enrolled 100 patients who underwent coronary angiography for clinically indicated reasons classified according to BMI into two groups, 50 patients (group A) with BMI ({u2265}30 kg/m2) and 50 patients (group B) with BMI {u2264}25 kg/m2. Severity of CAD was estimated with SYNTAX score and serum chemerin level was measured using ELIZA method. Results: serum chemerin level was higher in obese patients (p=0.019), and it was positively correlated with SYNTAX score (r=0.533, P<0.001), BMI, Waist circumference, FPG, LVMI and hs-CRP (all p <0.005). Serum chemerin levels were significantly increased with an increasing of number of diseased vessels (P=0.013). At multiple linear regression analysis serum chemerin level was found to be an independent predictor of SYNTAX score (Ý=0.432, p<0.001). Serum chemerin also was associated with LVH (p=0.004). Conclusion: Serum chemerin levels were higher in obese patients and were associated with LVH and inflammation. Also, it has a significant correlation with severity of coronary artery disease in Egyptian patients with coronary artery disease. Additional investigations are necessary to fully clarify the role of chemerin in cardiovascular disease

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