Serum 25 hydroxy colicalciferol and zinc levels in egyptian pediatric patients with inflammatory bowel disease (IBD) / Huda Zaghloul Abdelfattah ; Supervised Mohammad Ali Genena , Mohammad Nabih Almohammady , Dina Ali Ezzat

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Vitamin D is a fat-soluble vitamin important for normal bone metabolism because it facilitates intestinal calcium absorption and increase osteoblastic differentiation.Patients with Inflammatory Bowel Disease)IBD( are at increased risk for vitamin D deficiency. Another essential micronutrient, Zinc is an essential trace element, which is obsorbed in the small intestine. Prevalence of zinc deficiency with IBD during disease and in remission raging from15% to 40% .Objectives :To assess the prevalence of 25 Hydroxycolicalciferol and zinc deficiency in Egyptian pediatric patients with inflammatory bowel disease.Methods: History was taken from the patients including consanguinity, similar conditions, intestinal and extra intestinal manifestation and age of diagnosis.Assessment of disease activity were made using Pediatric crohn{u2019}s disease activity index (PCDAI).Pediatric ulcerative colitis activity index (PUCAL) Laboratory methods: Serum 25 Hydroxycolicalciferol: it will be assayed using enzyme linked immunosorbent assay technique (ELISA). Zinc will be assayed using atomic obsorption spectrometry.Results: This study found the serum vitamin D was statistically significantly lower among crohn{u2019}s cases (11.6± 4.4) than UC cases (19.9± 9.4) control cases (23.7 ± 10.8) (P<0.001) also serum zinc was statistically significantly lower among crohn{u2019}s cases (80.9± 27.8) than UC cases (95.1 ± 20.9) control cases (109±36.3) (p=0.045). Conclusion:25(OH)D deficiency and zinc deficiency is common in IBD patients. Serum 25 (OH)D levels and zinc were significantly lowest among moderate, followed by mild and highest in remission

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