Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Ancology (Medical)

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. They originate from the mesenteric ganglion cells, termed the interstitial Cajal cells. The majority, i.e. 95% of GIST, show expression of the membrane receptor protein CD117 with a tyrosine kinase activity c-kit. Gastrointestinal stromal tumors constitute less than 1% of all digestive tract tumors. They may be benign or malignant , and occur in every part of the gastrointestinal tract, however the stomach is the most common localization This is a retrospective study that was conducted through revision of medical records of 81 patients diagnosed with GIST who attend the department of Oncology in national cancer institute (NCI) in the period between 2006 to 2010 the following data were extracted from patient record Patient age.Complaint:Basis of diagno osis:Date of relapse:Date of last contact:Status of last contact:Treatment out come:The outcome will be discussed in relation to different prognosti c factor and treatment modalities

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