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Teratogenicity of the antibiotic drug ciprofloxacin on development offetuses of albino rats during pregnancy / Eman Shaarawy Sayed Ahmed ; Supervised Abdelwahab A. Elghareeb , Hamida Hamdi Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Shaarawy Sayed Ahmed , 2019Description: 70 P. : charts , facsimiles ; 25cmOther title:
  • التأثيرات المشوهة لعقارالمضاد الحيوى سيبروفلوكساسين على أجنة الجرذان البيضاء أثناء الحمل [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Ciprofloxacin is a broadspectrum antibiotic of the fluoroquinolone class. Because fluroquinolones are mainly used now for the treatment of urinary tract infections which have high incidence during pregnancy especially in the first trimester, and because fluroquinolones exert their effects via inhibition of nucleic acid synthesis, therefore this study was designed to evaluate the safety of the ciprofloxacin drug on development of offspring of albino rat during pregnancy .Pregnant albino rats (Rattus norvegicus) were administrated daily oral dose of 155mg/ Kg of body weight of ciprofloxacin from 5th day to 20th day of gestation. The animals were sacrificed at 20thday of gestation. Fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformations as well as histopathological studies of brain, liver and kidney
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Em.T (Browse shelf(Opens below)) Not for loan 01010110078679000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Em.T (Browse shelf(Opens below)) 78679.CD Not for loan 01020110078679000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Ciprofloxacin is a broadspectrum antibiotic of the fluoroquinolone class. Because fluroquinolones are mainly used now for the treatment of urinary tract infections which have high incidence during pregnancy especially in the first trimester, and because fluroquinolones exert their effects via inhibition of nucleic acid synthesis, therefore this study was designed to evaluate the safety of the ciprofloxacin drug on development of offspring of albino rat during pregnancy .Pregnant albino rats (Rattus norvegicus) were administrated daily oral dose of 155mg/ Kg of body weight of ciprofloxacin from 5th day to 20th day of gestation. The animals were sacrificed at 20thday of gestation. Fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformations as well as histopathological studies of brain, liver and kidney

Issued also as CD

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