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Cytokine receptor like factor 2 (CRLF2)- overexpressing pediatric Precursor B- acute lymphoblastic leukemia : An approach towards individualized therapy / Asmaa Mohamed Atef Abdelrahman ; Supervised Nayera Hamdy Elshakankiry , Emad Nabil Ebeid , Eman Omar Rasekh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Mohamed Atef Abdelrahman , 2020Description: 153 P. : charts , facsimiles ; 25cmOther title:
  • زيادة تعبير العامل المماثل للمستقبلات الخلوية-2 فى الأطفال المصابين بسرطان الدم الأولى ب الليمفاوى الحاد : نهج نحو العلاج الفردى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Introduction: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a neoplastic proliferation of lymphoblasts that has a gene expression profile similar to that of BCR-ABL1 positive B-ALL, but lacks the disease-defining Philadelphia chromosome. Growing evidence has proved that alterations in the cytokine receptor-like factor 2 gene (CRLF2)that result in CRLF2 overexpression associates with poor treatment outcomes thus highlighting a potentially important oncogenic mechanism in a subset of patients. The significant association of CRLF2 overexpression with JAK2 mutation suggests that these patients may benefit from future kinase inhibitor approaches. In addition, cell surface-expressed CRLF2 itself may be a potential target for anti-CRLF2 antibody based therapies
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2020.As.C (Browse shelf(Opens below)) Not for loan 01010110081145000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2020.As.C (Browse shelf(Opens below)) 81145.CD Not for loan 01020110081145000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Introduction: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a neoplastic proliferation of lymphoblasts that has a gene expression profile similar to that of BCR-ABL1 positive B-ALL, but lacks the disease-defining Philadelphia chromosome. Growing evidence has proved that alterations in the cytokine receptor-like factor 2 gene (CRLF2)that result in CRLF2 overexpression associates with poor treatment outcomes thus highlighting a potentially important oncogenic mechanism in a subset of patients. The significant association of CRLF2 overexpression with JAK2 mutation suggests that these patients may benefit from future kinase inhibitor approaches. In addition, cell surface-expressed CRLF2 itself may be a potential target for anti-CRLF2 antibody based therapies

Issued also as CD

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