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CD10, BCL6, and MUM1 algorithm expression in the extra-nodal bone marrow NHL diffuse large B-cell / Lobna Ahmed Abdelazim Refaat ; Supervised Zakaria Ismael Abdelhamid , Noha Mohamed Elhusseiny , Tarek Nabil Elbolkainy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Lobna Ahmed Abdelazim Refaat , 2019Description: 127 P. : charts , facsimiles ; 25cmOther title:
  • في النخاع العظمي لحالات سرطان الغدد الليمفاوية الغير هودجكين CD10, BCL6, and MUM1 دور [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non- Hodgkin lymphoma (NHL). DLBCL is characterized by biologic and pathogenetic heterogeneity. The aim of the study is to evaluate the reliability of the CD10-BCL6-MUM1 algorithm ICC in bone marrow biopsy (BMB) samples as additional prognostic and predictive decision making tool. Methods: This retrospective cohort study included 34 patients with confirmed diagnosis of DLBCL-NHL stage-IV with bone marrow dissemination. All BMB samples were routinely examined in the laboratory using H&E and immunohistochemistry study. Patients were evaluated using Hans classification depending on immunohistochemical detection of CD10, BCL6, and MUM1. Clinical evaluation was done based on the International Prognostic Index (IPI). Response to treatment and survival were assessed in relation to Hans classification and IPI
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2019.Lo.C (Browse shelf(Opens below)) Not for loan 01010110078850000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2019.Lo.C (Browse shelf(Opens below)) 78850.CD Not for loan 01020110078850000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non- Hodgkin lymphoma (NHL). DLBCL is characterized by biologic and pathogenetic heterogeneity. The aim of the study is to evaluate the reliability of the CD10-BCL6-MUM1 algorithm ICC in bone marrow biopsy (BMB) samples as additional prognostic and predictive decision making tool. Methods: This retrospective cohort study included 34 patients with confirmed diagnosis of DLBCL-NHL stage-IV with bone marrow dissemination. All BMB samples were routinely examined in the laboratory using H&E and immunohistochemistry study. Patients were evaluated using Hans classification depending on immunohistochemical detection of CD10, BCL6, and MUM1. Clinical evaluation was done based on the International Prognostic Index (IPI). Response to treatment and survival were assessed in relation to Hans classification and IPI

Issued also as CD

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