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Pharmaceutical study on certain transdermal drug delivery systems / Mohamed Azmi Ahmed Mohamed ; Supervised Saadia A.Tayel , Mohamed Ahmed Elnabarawi , Randa Tag Abderehim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Azmi Ahmed Mohamed , 2021Description: 147 P. : charts ; 25cmOther title:
  • دراسة صيدلية لبعض الأنظمة العابرة للجلد [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Hypertension affects approximately one billion individual worldwide, it is associated with an elevated risk of mortality and morbidity and it has a negative impact on quality of life.Occurrence of hypertension is very high in adults; so there is a great need for development of non-oral way for drug application is currently the most important approach. Bisoprolol Hemifumarate (BH) is a member of beta-blockers group. This is a class of drugs used mainly in cardiovascular diseases. It is a selective beta-1 receptor blocker that significantly decreases high blood pressure, treats reduced blood flow to the heart (cardiac ischemia) by reducing heart muscle activity, so decreases oxygen and nutrient demand i.e. low blood supply can transport required amounts of oxygen and nutrients CHF and decreases recurrence of heart attacks. BH has several advantages such as good tolerability and decreases sodium currents in CHF also have anti-arrhythmic effects.This study aims to develop a new dosage form of BH for treatment of elderly patients using transdermal delivery systems since BH can be used in transdermal application due to its apparent partition coefficient of 4.07 which indicates good skin permeability
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Mo.P (Browse shelf(Opens below)) Not for loan 01010110084080000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Mo.P (Browse shelf(Opens below)) 84080.CD Not for loan 01020110084080000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Hypertension affects approximately one billion individual worldwide, it is associated with an elevated risk of mortality and morbidity and it has a negative impact on quality of life.Occurrence of hypertension is very high in adults; so there is a great need for development of non-oral way for drug application is currently the most important approach. Bisoprolol Hemifumarate (BH) is a member of beta-blockers group. This is a class of drugs used mainly in cardiovascular diseases. It is a selective beta-1 receptor blocker that significantly decreases high blood pressure, treats reduced blood flow to the heart (cardiac ischemia) by reducing heart muscle activity, so decreases oxygen and nutrient demand i.e. low blood supply can transport required amounts of oxygen and nutrients CHF and decreases recurrence of heart attacks. BH has several advantages such as good tolerability and decreases sodium currents in CHF also have anti-arrhythmic effects.This study aims to develop a new dosage form of BH for treatment of elderly patients using transdermal delivery systems since BH can be used in transdermal application due to its apparent partition coefficient of 4.07 which indicates good skin permeability

Issued also as CD

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