Thesis (M.Sc.) - Cairo University - National Institute of laser Enhanced Sciences (NILES) - Department of Laser Application in Environmental Metrology Photochemistry Agriculture

The conventional synthetic method of 1,2,3-triazoles is [3+2]-dipolar cycloaddition between alkynes and organic azides, which generally provides a mixture of 1,4- and 1,5-regio-isomers. The most important developments were achieved in this area by the copper catalyzed azide{u2013}alkyne cycloaddition (CuAAC) to obtain the 1,4-disubstituted isomer. In this study, CuO nanoparticles (NPs) and CuO/NiO nanocomposites (NCs) were synthesized with the aim of achieving [3+2] cycloaddition of organic azides with terminal alkynes under microwave irritations. The reaction showed in all cases the exclusive formation of the 1,4-isomer.The results reveled that that the CuO/NiO NCs showed potential catalytic performance than CuO NPs. This strategy features the use of microwave irradiation resulted in short reaction time, high yielding products, and selectivity. Therefore, it was expected that the as-prepared CuO/NiO nanocatalyst is a promising catalytic system for click reaction

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