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Evaluation of the classical complement pathway in activation of rheumatoid arthritis / Marwa Salah Elsayed Shabana ; Supervised Samia Mohamad Hassan Fadda , Azza Ahmed Aboulenein , Hanan Elsayed Ali Darweesh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Salah Elsayed Shabana , 2014Description: 136 Leaves : charts ; 30cmOther title:
  • تقييم المسار الكلاسيكى المتمم فى نشاط الروماتيود المفصلى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation Summary: Complement activation has been implicated in the pathogenesis of RA. C1q {u2013} C4 complexes are a specific parameter of classical pathway activation. We aimed to investigate plasma levels of complement parameter; C1q and activated C4 in rheumatoid arthritis, and also to assess their association with disease activity. 50 RA patients classified into inactive RA group whose DAS 28 < 2.6 (n = 23 / 50) and active group had DAS 28 {u2265} 2.6 (n = 27 / 50) and control group (n = 20). RA patients were submitted to full history taking, full clinical examination, routine laboratory investigations, assessment of disease activity. CIq antibodies and C4d antibodies were measured using enzyme - linked Immunosorbent assay (ELISA) technique
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Ma.E (Browse shelf(Opens below)) Not for loan 01010110063809000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Ma.E (Browse shelf(Opens below)) 63809.CD Not for loan 01020110063809000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation

Complement activation has been implicated in the pathogenesis of RA. C1q {u2013} C4 complexes are a specific parameter of classical pathway activation. We aimed to investigate plasma levels of complement parameter; C1q and activated C4 in rheumatoid arthritis, and also to assess their association with disease activity. 50 RA patients classified into inactive RA group whose DAS 28 < 2.6 (n = 23 / 50) and active group had DAS 28 {u2265} 2.6 (n = 27 / 50) and control group (n = 20). RA patients were submitted to full history taking, full clinical examination, routine laboratory investigations, assessment of disease activity. CIq antibodies and C4d antibodies were measured using enzyme - linked Immunosorbent assay (ELISA) technique

Issued also as CD

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