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Anticancer compounds from chaetomium globosum / Eman Hamed Mohamed Abdelrahim ; Supervised Mohamed Hani Moubasher

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Hamed Mohamed Abdelrahim , 2015Description: 81 P. : photographs ; 25cmOther title:
  • مركبات مضادة للسرطان من فطر الكيتوميوم جلوبوسوم [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany and Microbiology Summary: The present work resulted in extraction and purification of five potential anticancer compounds from chaetomium globosum Kunze, which was isolated from Egyptian soil. Two of these compounds were tested against michigan cancer foundation 7 (MCF 7) breast cancer cell line, Hepatocellular carcinoma, Human (HEPG 2) a human liver carcinoma cell line and COS cells [CV 1 (simian) in origin, and carrying the SV40 genetic material] a fibroblast-like cell line derived from monkey kidney tissue, showed inhibition effect against the proliferation of the three tested cell lines. Structures of two of the five pure compounds were elucidated by ¹HNMR and Mass spectroscopy as methyl 2, 9, dihydro 1, 2, 8, trihydroxy 9 oxo 1H xanthene 1 carboxylate as a member of xanthones and (E) methyl 2, hydroxy 6, 6, dimethyl hept 3 enoate
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.M.Sc.2015.Em.A (Browse shelf(Opens below)) Not for loan 01010110068261000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.M.Sc.2015.Em.A (Browse shelf(Opens below)) 68261.CD Not for loan 01020110068261000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany and Microbiology

The present work resulted in extraction and purification of five potential anticancer compounds from chaetomium globosum Kunze, which was isolated from Egyptian soil. Two of these compounds were tested against michigan cancer foundation 7 (MCF 7) breast cancer cell line, Hepatocellular carcinoma, Human (HEPG 2) a human liver carcinoma cell line and COS cells [CV 1 (simian) in origin, and carrying the SV40 genetic material] a fibroblast-like cell line derived from monkey kidney tissue, showed inhibition effect against the proliferation of the three tested cell lines. Structures of two of the five pure compounds were elucidated by ¹HNMR and Mass spectroscopy as methyl 2, 9, dihydro 1, 2, 8, trihydroxy 9 oxo 1H xanthene 1 carboxylate as a member of xanthones and (E) methyl 2, hydroxy 6, 6, dimethyl hept 3 enoate

Issued also as CD

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