Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Surgical)

Colorectal cancer is the 3rd leading cause of cancer related deaths in males and females. The liver is the most common site of distant disease in colorectal cancer and approximately 60% of patients will develop liver metastases at some point during the course of their disease. Metastatic disease of the liver was considered a lethal disease. Untreated metastatic colorectal carcinoma has a median survival of 6 to 9 months. Also using chemotherapy in the treatment of multiple colorectal cancer metastases was not so successful with median survival rate of 16.2 months.This study reviewed the history and evolution of therapies used for the management of metastatic colorectal cancer to the liver. Improvements in surgical technique, imaging and systemic therapy have led to expand the criteria of resectability; actually, the only sure contraindication for hepatic resection in management of multiple colorectal liver metastases is the inability to achieve margin-negative resection while ensuring sufficient hepatic reserve

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