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Clinical significance of matrix metalloproteinase-2, -9(MMP-2 & MMP-9) & tissue inhibitor of matrix metalloproteinase-1(TIMP-1) in childhood Acute lymphoblastic leukemia : Relation with DNA content / Mohamed Ahmed Ahmed Khalil ; Supervised Mohammed Abdelazim Albaddini , Emad Nabil Ebeid , Maha Saleh Madbouly

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Ahmed Ahmed Khalil , 2010Description: 121 P. : charts ; 25cmOther title:
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) regulate the turnover of the extracellular matrix and modulate the biology of hematopoietic cell. MMP-2.-9 & TIMP-1 play a fundamental role in tumor invasion and metastasis. This study aimed to finding a correlation between the expression of these markers and extramedullary involvement as well as in pediatric acute lymphoblastic leukemia (ALL).Results revealed a statistically significant difference in TLC among MMP9 & TIMP1 positive cases. Hepatomegaly showed statistically significant higher incidence among MMP9 positive cases and CD34 expression showed a statistically significant higher incidence in MMP2 positive group
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2010.Mo.C (Browse shelf(Opens below)) Not for loan 01010110066663000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2010.Mo.C (Browse shelf(Opens below)) 66663.CD Not for loan 01020110066663000

Date of disscussion 2015

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) regulate the turnover of the extracellular matrix and modulate the biology of hematopoietic cell. MMP-2.-9 & TIMP-1 play a fundamental role in tumor invasion and metastasis. This study aimed to finding a correlation between the expression of these markers and extramedullary involvement as well as in pediatric acute lymphoblastic leukemia (ALL).Results revealed a statistically significant difference in TLC among MMP9 & TIMP1 positive cases. Hepatomegaly showed statistically significant higher incidence among MMP9 positive cases and CD34 expression showed a statistically significant higher incidence in MMP2 positive group

Issued also as CD

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