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Micro RNA 192 as a new biomarker in the diagnosis of HCC / Ola Mohammad Abdullah Elsaid Othman ; Supervised Abeer Mohamed Mohy Eldeen Elsaid , Hadeel Mohammad Elhanafi , Reham Aly Abbas Elshimy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ola Mohammad Abdullah Elsaid Othman , 2019Description: 114 P. : charts , facsimiles ; 25cmOther title:
  • استخدام حمض الريبونيكليك متناهي الصغر 192 كدلالة تشخيصية جديدة في مرضى سرطان الكبد [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background& Objective:Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. MicroRNAs regulate at least 60% of human genes, including tumour suppressor genes and oncogenes and, thereby, can affect cancer risk.MiRNA-192 is thought to be positive regulator of p53, a human tumor suppressor. They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets. It has also been suggested that miR-192 could be used as a biomarker for drug-induced liver damage. Aim of the work: In the present study, miRNA-192 expression levels (thought to be positive regulator of p53)in human HCC serum is intended to be examined by specific qRT-PCR to detect its role in HCC. Subjects &Methods:Fiftytwo newly diagnosed HCC cases and 30 apparently healthy individuals were recruited in this study. MiRNA-192 level was measured by TaqMan- Real time PCR assay
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2019.Ol.M (Browse shelf(Opens below)) Not for loan 01010110078568000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2019.Ol.M (Browse shelf(Opens below)) 78568.CD Not for loan 01020110078568000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background& Objective:Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. MicroRNAs regulate at least 60% of human genes, including tumour suppressor genes and oncogenes and, thereby, can affect cancer risk.MiRNA-192 is thought to be positive regulator of p53, a human tumor suppressor. They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets. It has also been suggested that miR-192 could be used as a biomarker for drug-induced liver damage. Aim of the work: In the present study, miRNA-192 expression levels (thought to be positive regulator of p53)in human HCC serum is intended to be examined by specific qRT-PCR to detect its role in HCC. Subjects &Methods:Fiftytwo newly diagnosed HCC cases and 30 apparently healthy individuals were recruited in this study. MiRNA-192 level was measured by TaqMan- Real time PCR assay

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