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MicroRNA-215 as a diagnostic marker in Egyptian patients with hepatocellular carcinoma / Hussein Ahmed Ali Elmahdy ; Supervised Ismail Abdelshafy Abdelhamid , Mona Mahmoud Hassouna , Ahmed Ibrahim Amen

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hussein Ahmed Ali Elmahdy , 2020Description: 142 P. : charts , facsimiles ; 25cmOther title:
  • تقييم الحمض النووى الريبوزى المتناهى الصغر 215 كدلالة تشخيصية فى المرضى المصريين المصابين بسرطان الكبد [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and the third leading cause of cancer-related death. In Egypt, 80% of the patients with hepatocellular carcinoma have underling hepatitis C. MicroRNAs are reported as a group of small non-coding RNAs and aberrant miRNA expression has been reported in HCC patients or cell lines. We aimed to assess diagnostic value of plasma MicroRNA-215 in patients with hepatocellular carcinoma. Methods: A prospective study included 195 subjects divided into 3 groups: healthy controls (group I), Cirrhotic patients (group II), and patients with HCC (group III); all cases were subjected to thorough clinical examination, radiological and laboratory investigations which included quantification of miR-215 by Real- Time qPCR In conclusion, Plasma level of miR-215 might be considered as potential biomarker for diagnosis of HCC. Moreover, miR-215 combined with AFP can be used as a diagnostic biomarker, for early detection of HCC
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2020.Hu.M (Browse shelf(Opens below)) Not for loan 01010110081184000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2020.Hu.M (Browse shelf(Opens below)) 81184.CD Not for loan 01020110081184000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and the third leading cause of cancer-related death. In Egypt, 80% of the patients with hepatocellular carcinoma have underling hepatitis C. MicroRNAs are reported as a group of small non-coding RNAs and aberrant miRNA expression has been reported in HCC patients or cell lines. We aimed to assess diagnostic value of plasma MicroRNA-215 in patients with hepatocellular carcinoma. Methods: A prospective study included 195 subjects divided into 3 groups: healthy controls (group I), Cirrhotic patients (group II), and patients with HCC (group III); all cases were subjected to thorough clinical examination, radiological and laboratory investigations which included quantification of miR-215 by Real- Time qPCR In conclusion, Plasma level of miR-215 might be considered as potential biomarker for diagnosis of HCC. Moreover, miR-215 combined with AFP can be used as a diagnostic biomarker, for early detection of HCC

Issued also as CD

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