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Pharmacogenomics of thrombolytic therapy effect of gene polymorphisms on response to streptokinase in patients with acute myocardial infarction / Maha Mohamed Saber Khalil ; supervised Haider Abbas Ghaleb , Sherif Mokhtar , Abd El - Fattah Hassan Marrie

By: Contributor(s): Language: Eng Publication details: Cairo : Maha Mohamed Saber Khalil , 2006Description: 183P : ill ; 25cmOther title:
  • الفارماكولوجيا الجينية للعلاج بمذيبات الجلطة : تأثير التنوع الجينى على الاستجابة للستريبتوكاينيز فى مرضى احتشاء القلب الحاد [Added title page title]
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Dissertation note: Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Pharmacology Summary: This study is an attempt to assess the possible effect of 4 different gene polymorphisms on patient's response to streptokinase after acute myocardial infarctionTo achieve this goal , we studied 63 patients with acute anterior myocardial infarction (mean age : 543 ± 972 years , range : 34 - 76 years) , Besides clinical relief of chest pain , patients' response to thrombolytic therapy was evaluated using ST - segment elevation both on admission and 2 hours following SK administrationWe used the ST - segment resolution for assessment of responseFifty percent STR was considered as a sign of effective reperfusionFor each patient DNA was extracted from a peripheral blood sampleFor each gene polymorphism we used the specific primers for Restriction fragment length polymorphism (RFLP) - technique : Polymerase chain reaction (PCR) followed by the specific restriction enzymeOut of the 63 pts studied for ACE insertion / deletion genotyping , fifty percent STR was most frequently observed in 100
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Item type Current library Home library Call number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.29.Ph.D.2006.Ma.P. (Browse shelf(Opens below)) Not for loan 01010110045320000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.29.Ph.D.2006.Ma.P. (Browse shelf(Opens below)) Not for loan 01020110045320000

Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Pharmacology

This study is an attempt to assess the possible effect of 4 different gene polymorphisms on patient's response to streptokinase after acute myocardial infarctionTo achieve this goal , we studied 63 patients with acute anterior myocardial infarction (mean age : 543 ± 972 years , range : 34 - 76 years) , Besides clinical relief of chest pain , patients' response to thrombolytic therapy was evaluated using ST - segment elevation both on admission and 2 hours following SK administrationWe used the ST - segment resolution for assessment of responseFifty percent STR was considered as a sign of effective reperfusionFor each patient DNA was extracted from a peripheral blood sampleFor each gene polymorphism we used the specific primers for Restriction fragment length polymorphism (RFLP) - technique : Polymerase chain reaction (PCR) followed by the specific restriction enzymeOut of the 63 pts studied for ACE insertion / deletion genotyping , fifty percent STR was most frequently observed in 100

Issued also as CD

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