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Cellular and humoral immune response to gram positive and gram negative bacteria in BALB/c mice treated with elapids, vipers and bee venom as natural products for treatment of bacterial infection / Samah Gomaa Mohamed Gad Elrab ; Supervised Azza Elamir , Wajeet Nabil Said , Lamiaa Salah Eldin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samah Gomaa Mohamed Gad Elrab , 2021Description: 143 P. : charts , facsimiles , photoghraphs ; 25cmOther title:
  • دراسة الاستجابة المناعية الخلوية و الخلطيه للفئران المصابة بالبكتيريا الموجبة و السالبة الجرام باستخدام سموم الثعابين و الافاعي و النحل كمنتجات طبيعيه لمعالجة العدوى البكتيرية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: Bacterial strains resistance represents a serious problem in the field of health protection, therefore many researches directed to discover some alternative natural products as antibacterial, nowadays special attention towards venoms as elapids, viprides, bee venom,et. which contain molecules with antibacterial and bacteriostatic properties.The present study aimed to evaluate in vivo and in vitro antibacterial effect of three different venoms the Egyptian Cobra (Naja haje), the horned viper (Cerastes cerastes) and honey bee (Apis mellifera) on both Staphylococcus aureus as Gram positive bacteria and Salmonella typhi as Gram negative bacteria by MIC test and disc diffusion method as in vitro evaluation, safety study was performed before and after the evaluation of antibacterial effect of the three different venoms, by i.p. injection of 1/10 LD50 using Swiss albino mice groups.Complete blood picture showed a significant decrease in both hemoglobin (Hb) concentration and red blood cells (RBCs) in all venoms groups except N. haje Hb increased, platelets and WBCs count showed significant increase in both N. haje and C. cerastes while A. mellifera decreased WBCs. N. haje and C. cerastes venoms showed the significant increase in liver alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and kidney functions (urea and creatinine) in addition to cardiac enzyme creatinine phosphokinase (CPK), while A. mellifera treated group showed no significant change compared to control group.Histological examination showed minor alterations in liver, kidney and cardiac tissues of mice with both N. haje and C. cerastes treatment while A. mellifera has no effect on tissue
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Sa.C (Browse shelf(Opens below)) Not for loan 01010110084960000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Sa.C (Browse shelf(Opens below)) 84960.CD Not for loan 01020110084960000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

Bacterial strains resistance represents a serious problem in the field of health protection, therefore many researches directed to discover some alternative natural products as antibacterial, nowadays special attention towards venoms as elapids, viprides, bee venom,et. which contain molecules with antibacterial and bacteriostatic properties.The present study aimed to evaluate in vivo and in vitro antibacterial effect of three different venoms the Egyptian Cobra (Naja haje), the horned viper (Cerastes cerastes) and honey bee (Apis mellifera) on both Staphylococcus aureus as Gram positive bacteria and Salmonella typhi as Gram negative bacteria by MIC test and disc diffusion method as in vitro evaluation, safety study was performed before and after the evaluation of antibacterial effect of the three different venoms, by i.p. injection of 1/10 LD50 using Swiss albino mice groups.Complete blood picture showed a significant decrease in both hemoglobin (Hb) concentration and red blood cells (RBCs) in all venoms groups except N. haje Hb increased, platelets and WBCs count showed significant increase in both N. haje and C. cerastes while A. mellifera decreased WBCs. N. haje and C. cerastes venoms showed the significant increase in liver alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and kidney functions (urea and creatinine) in addition to cardiac enzyme creatinine phosphokinase (CPK), while A. mellifera treated group showed no significant change compared to control group.Histological examination showed minor alterations in liver, kidney and cardiac tissues of mice with both N. haje and C. cerastes treatment while A. mellifera has no effect on tissue

Issued also as CD

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