000 027930000a22003490004500
003 EG-GICUC
005 20250223024907.0
008 061012s2006 ua a f m 000 0 eng d
040 _aEG-GICUC
_beng
_cEG-GICUC
041 0 _aEng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.02.M.Sc.2006.Ad.R.
100 0 _aAdel Shehata Mohamed Ali
245 1 0 _aRole of serum interleukin - 6 in prediction of bone loss in postmenopausal women /
_cAdel Shehata Mohamed Ali ; Supervised Fawzy ali attaby , Ahmed elsayed abd allah , Merveet elsayed mohamed
246 1 5 _aدور الانتركولين 6 فى التنبؤ بهشاشة العظام فى السيدات بعد انقطاع الطمث
260 _aCairo :
_bAdel Shehata Mohamed Ali ,
_c2006
300 _a160P :
_bill ;
_c30cm
502 _aThesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Biochemistry
520 _aOsteoporosis is defined as reduction of bone mass or density or the presence of fragility fractureThis reduction in bone tissue is accompanied by deterioration in the architecture of the skeleton , leading to a markedly increased risk of fractureBone mass increase during growth to reach a peak between age of 25 and 35 and falls there after in both sexesThe presence study was conducted on 80 subject classified into four groups according to the duration of menopause all subject will be exposed to ; clinical examination , bone mineral density measurement and biochemical assays including interleukin - 6 and osteocalcinThere is recent evidence that the protection effect of estrogen on the skeleton may also be important in older postmenopausal womenA direct effect of estrogen on bone cells function may be involved as well as and indirect effect on extraskeletal calcium homeostasisEstrogen deficiency dramatically alters the dependency of bone cells on several cytokines including IL - 6 , IL - 1 and INFInterleukin - 6 is a cytokine , Produced by many different cell type including Immune cells and adipose tissue that mediates inflammatory responseUnlike other cytokines interleukin - 6 is unusual in that its major effect takes place at sites distant from its origin and are consequent upon its circulation concentrationWe conclude that interleukin - 6 appears to be a potent osteotropic factor that may play an important role in prediction
530 _aIssued also as CD
653 4 _aAlkaline Phosphatase
653 4 _abone alkaline Phosphatase
653 4 _aCalcium
700 0 _aAhmed ElSayed Abd Allah ,
_eSupervisor
700 0 _aFawzay Ali Attaby ,
_eSupervisor
700 0 _aMerveet ElSayed Mohamed ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAmira
_eCataloger
905 _aMustafa
_eRevisor
942 _2ddc
_cTH
999 _c1338
_d1338