000 | 04881namaa22004331i 4500 | ||
---|---|---|---|
003 | OSt | ||
005 | 20240211192452.0 | ||
008 | 231121s2022 ua a|||frm||| 000 0 eng d | ||
040 |
_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda |
||
041 | 0 |
_aeng _beng _bara |
|
043 | _af-ua--- | ||
049 | _aDeposit | ||
082 | 0 | 4 |
_a616.99462 _221 |
092 |
_a616.99462 _221 |
||
097 | _aM.Sc | ||
099 | _aCai01.19.04.M.Sc.2022.Ha.C | ||
100 | 0 |
_aHagar Shahin Ismail ALzawawy, _epreparation. |
|
245 | 1 | 0 |
_aComparing results of neoadjuvant chemotherapy versus adjuvant in high risk bladder cancer patients, NCI, Egypt / _cby Hagar Shahin Ismail ALzawawy ; under supervision of Dr. Marwa Nabil Abdelhafez, Dr. Ibrahim Abdelaziz Malash. |
246 | 1 | 5 | _a دراسة استرجاعية للمقارنة بين فوائد العلاج الكيميائى ما قبل العملية و العلاج المساعد فى سرطان المثانة عالية المخاطر للمرضى المترددين بالمعهد القومى للاورام مصر |
264 | 0 | _c2022. | |
300 |
_a70 pages : _billustrations ; _c25 cm. + _eCD. |
||
336 |
_atext _2rdacontent |
||
337 |
_aUnmediated _2rdamedia |
||
338 |
_avolume _2rdacarrier |
||
502 | _aThesis (M.Sc.)-Cairo University, 2022. | ||
504 | _aBibliography: pages 34-45. | ||
520 | _aBladder cancer is one of the most prevalent cancers globally. Men have a 34-fold higher rate of cancer than women. The gold standard treatment for muscle-invasive bladder cancer is a radical cystectomy (RC). Objective: The present study aimed to assess effectiveness of neoadjuvant chemotherapy on size of tumor; assess the treatment outcome (overall survival and progression free survival) of all cases of urinary bladder cancer. Patients and Methods: The present study aimed to assess effectiveness of neoadjuvant chemotherapy on size of tumor; assess the treatment outcome (overall survival and progression free survival) of all cases of urinary bladder cancer. Most patients presented in an advanced stage of the disease (stages 3 and 4: 60.8% and 17.7%, respectively); (69.6%) of patients had a history of Schistosomiasis. Results: Patients who received neoadjuvant chemotherapy had higher 2-year OS than patients who received adjuvant chemotherapy (56% vs. 48.4%). Patients who received neoadjuvant chemotherapy had higher median OS than patients who received adjuvant chemotherapy (25.1 vs. 22.0 months). Females exhibited a considerably greater 2-year cumulative relapse rate than males (P = 0.010). Patients aged > 50 years having a greater 2-year cumulative incidence of recurrence than patients aged 50 year (P = 0.179). Squamous and Transitional cell histologies (vs. Papillary) connected with a greater risk of recurrence (P = 0.23 and 0.17). Conclusion: Patients who received neoadjuvant chemotherapy had higher OS than patients who received adjuvant chemotherapy. Females exhibited a considerably greater cumulative relapse rate than males. There was statistically significant correlation between gender and recurrence risk. | ||
520 | _aيعد سرطان المثانة أحد أكثر أنواع السرطان انتشارًا على مستوى العالم. الرجال لديهم 34 ضعفا نسبة الإصابة بالسرطان أعلى من النساء. العلاج القياسي الذهبي للمثانة الغازية للعضلات السرطان هو استئصال المثانة الجذري (RC). الهدف: تهدف الدراسة الحالية إلى تقييم فعالية العلاج الكيميائي المساعد الجديد على حجم الورم تقييم نتائج العلاج (البقاء على قيد الحياة بشكل عام والبقاء على قيد الحياة بدون تقدم). جميع حالات سرطان المثانة البولية. المرضى والطرق: تهدف الدراسة الحالية إلى تقييم فعالية المواد المساعدة الجديدة العلاج الكيميائي على حجم الورم. تقييم نتائج العلاج (البقاء الشامل والتقدم البقاء على قيد الحياة مجانا) لجميع حالات سرطان المثانة البولية. معظم المرضى قدموا في حالة متقدمة | ||
530 | _aIssues also as CD. | ||
546 | _aText in English and abstract in Arabic & English. | ||
650 | 0 |
_aBladder _xCancer. |
|
653 | 0 | _aNeoadjuvant Chemotherapy | |
700 | 0 |
_aMarwa Nabil Abdelhafez, _ethesis advisor. |
|
700 | 0 |
_aIbrahim Abdelaziz Malash, _ethesis advisor. |
|
700 | 0 |
_aEman Nagib Khorshed, _ethesis advisor. |
|
900 |
_b01-01-2022 _cMarwa Nabil Abdelhafez _cIbrahim Abdelaziz Malash _cEman Nagib Khorshed _UCairo University _FNational Cancer Institute _DDepartment of Medical Oncology |
||
905 | _aHanan | ||
942 |
_2ddc _cTH _e21 _n0 |
||
999 |
_c165751 _d165751 |