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_beng
_cEG-GICUC
_dEG-GICUC
_erda
041 0 _aeng
_beng
_bara
049 _aDeposit
082 0 4 _a618.92994
_221
092 _a618.92994
_221
097 _aM.Sc
099 _aCai01.19.05.M.Sc.2022.Mu.E
100 0 _aMuhammad Ahmed Muhammad al-sabagh,
_epreparation.
245 1 4 _aThe expression of CD79a in B-cell acute lymphoblastic leukemia (all) and its effect on the outcome /
_cby Muhammad Ahmed Muhammad Alsabagh ; supervisors Asmaa Mohamed Hamoda, Eman Zaghloul Kandeel, Sally Talaat Khattab.
246 1 5 _aالتأثير التعبير الأولى ل (سي دى 79 الفا ) على نتائج علاج سرطان الدم اليمفاوي من نوع الخلايا (ب) في الأطفال
264 0 _c2022.
300 _axii, 111 pages :
_billustrations ;
_c25 cm. +
_eCD.
336 _atext
_2rdacontent
337 _aUnmediated
_2rdamedia
338 _avolume
_2rdacarrier
502 _aThesis (M.Sc.)-Cairo University, 2022.
504 _aBibliography: pages 89-101.
520 _aCentral nervous system (CNS) involvement is a challenge in diagnosis & treatment. Diagnosis and treatment of central nervous system (CNS) infiltration and/or CNS relapse in childhood acute lymphoblastic leukemia (ALL) remain challenging. CNS leukemia is mainly a leptomeningeal disease, but leukemic cells may be detectable in the cerebrospinal fluid.The study aimed to assess the relation between CD79a expression on BM sample and overall, EFS and CNS involvement in B-cell ALL (ALL). Patients and methods: A retrospective study of expression of CD79a in 331 patients with pediatric B cell ALL, treated according to St. Jude total XV protocol at National Cancer Institute, Cairo University between January 2012 to December 2018. Results: the incidence of CNS involvement initially, there was 10 (3%) patients (CNS III),median value of CD79a expression in CNS III was as the following: 85.5 % ,MFI:140.0 MFI-ISO: 128.0 MFI\ISO: 10.6 , while in (CNS I) was as the following, 42.0 % , MFI: 74.0 , MFI-ISO:59.0, MFI\ISO:4.8. Regarding the CNS relapse, There is a strong relation between the degree of expression of CD79a in initial BM sample and the site of relapse, in isolated CNS and combined relapse showed higher level of expression of CD79a than hematological relapse. In isolated CNS relapse the median percentage of expression: 85, MFI:190, MFI\ISO:95,MFI-ISO:177,in combined relapse median percentage of expression:89,MFI:185,MFI\ISO:17.6,MFI-ISO:173 ,While hematological relapse:67,MFI:86,MFI\ISO:5.2,MFI-ISO:9.5. There is a Signiant impact of qualitative and qualitative expression of CD79a and the OS of Population who expressed percentage below(43.0) showed lower OS than patients who expressed above (43.0), P value ( <0.001), As regard MFI of expression of CD79a on initial BM sample , we have calculated it with cut point (77) the mean value of the expression on the whole cohort. It is significant impact on XII the OS , population who MFI below(77) showed lower OS than patients who expressed above (77), P value ( <0.001), As regard MFI\ISO of expression of CD79a on initial BM sample, we have calculated it with cut point (4.8) the mean value of the expression on the whole cohort. Conclusions: There is direct relation and impact on OS & EFS between quantitative CD79a on BM on CNS and site of relapse.
520 _aسرطان الدم اللمفاوى الحاد هو اكثر انواع سرطان الاطفال شيوعا و هو الانت يشهد نسبا كبيرة من الشفاء نتيجة لتصنيف العلاج علة اساس علم الوراثة الخلوية و الجزيئية و التنميط المناعى سرطان الدم اللمفاوى الحاد مسؤول عن 25% من جميع الاورام الخبيثة لدى الاطفال و 75% من سرطان الدم لدى الاطفال
530 _aIssues also as CD.
546 _aText in English and abstract in Arabic & English.
650 0 _aTumors in children.
653 0 _aLymphoblastic
_aCD79a
700 0 _aAsmaa Mohamed Hamoda,
_ethesis advisor.
700 0 _aSally Talaat Khattab,
_ethesis advisor.
700 0 _aEman Zaghloul Kandeel,
_ethesis advisor.
856 _uhttp://172.23.153.220/th.pdf
900 _b01-01-2022
_cAsmaa Mohamed Hamoda
_cEman Zaghloul Kandeel
_cSally Talaat Khattab
_UCairo University
_FNational Cancer Institute
_DDepartment of Pediatric Oncology
905 _aHanan
_eEssam
942 _2ddc
_cTH
_e21
_n0
999 _c165808
_d165808