000			032710000a22003370004500
003			EG-GICUC
005			20250223024944.0
008			061029s2006 ua a f m 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC
041	0		_aEng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.04.M.Sc.2006.As.S.
100	0		_aAsmaa Elsayed Abdellatief Kassab
245	1	0	_aSynthesis of Certain Fused Thienopyrimidines of Biological Interest / _cAsmaa Elsayed Abdellatief Kassab ; Supervised Bothaina Abdelfattah Mousa , Manal Mostafa Kandeel , Omneya Mahmoud Khalil
246	1	5	_aتشييد بعض مشتقات الثينوبيريميدينات الملتحمة ذات الاهمية البيولوجية
260			_aCairo : _bAsmaa Elsayed Abdellatief Kassab , _c2006
300			_a141P : _bill ; _c30cm
502			_aThesis (M.Sc.) - Cairo University - Faculty Of Pharmacy - Department Of Organic Chemistry
520			_aThe thesis is prefaced by an account on the synthesis of cycloalkeno - thieno[2 , 3 - d]pyrimidin - 4 (3H) - ones and triazolocycloalkenothienopyrimidine derivativesIn addition , a survey covering the different biological activities of some cycloalkenothienopyrimidines and their fused systems is givenPreparation of the root compounds vizethyl 2 - aminocycloocteno - [b]thiophene - 3 - carboxylate (II) , ethyl 2 - (3 - substituted thioureido) cycloocte - no[b]thiophene - 3 - carboxylates (IIIa and b) , 3 - substituted - 2 - thioxo - 1H , 3H - cyc - loocteno[4 , 5]thieno[2 , 3 - d]pyrimidin - 4 - ones (IVa and b) and 3 - amino - 2 - substit - uted aminocycloocteno[4 , 5]thieno[2 , 3 - d]pyrimidin - 4 (3H) - ones (XIIa and b) is presentedScheme 1 is concerned with the interaction of the ortho amino ester II with isothiocyanates to furnish IIIa and bFurthermore , cyclization of the latter was accomplished smoothly in ethanol saturated with dry hydrogen chloride to give the 2 - mercaptothienopyrimidin - 4 (3H) - ones IVa and b which was alkylated using different alkyl halides (methyl iodide , ethyl iodide and allyl bromide) to afford Va - fs regards Scheme 2 , it involves the reaction of IVa and b with ethyl chloroacetate to give 2 - ethoxycarbonylmethylthio - 3 - substituted cyclooct - eno[4 , 5]thieno[2 , 3 - d]pyrimidin - 4 (3H) - ones (VIa and b) Reaction of the latter with hydrazine hydrate gave the corresponding hydrazide VIIa and bCondensation of VIIa and b with different aromatic ketones (acetophenone , 4 - chloroacetophenone , 4 - aminoacetophenone and 4 - hydroxyacetophenone) afforded the corresponding arylethylidene derivatives VIIIa - hThe reaction of VIIIa - h with acetic anhydride yielded 2 - (acetyloxyethynylthio) - 3 - substituted cycloocteno[4 , 5]thieno[2 , 3 - d]pyrimidin - 4 (3H) - ones (XIa and b) , instead of expected 1 , 3 , 4 - oxadiazoline derivativesIn addition , 3 - phenyl -
530			_aIssued also as CD
653		4	_aBiological Interest
653		4	_aFused Thienopyrimidines
700	0		_aBothaina Abd El Fattah Mousa , _eSupervisor
700	0		_aManal Mostafa Kandeel , _eSupervisor
700	0		_aOmneya Mahmoud Khalil , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aEsam _eRevisor
942			_2ddc _cTH
999			_c2548 _d2548