000 025620000a22003490004500
003 EG-GICUC
005 20250223030037.0
008 061211s2006 ua d f m 000 0 eng d
040 _aEG-GICUC
_beng
_cEG-GICUC
041 0 _aEng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.02.M.Sc.2006.Do.S.
100 0 _aDoaa Ezzat Said Ahmed
245 1 0 _aStudy of some biochemical parameters in lymphoid and myeloid leukemia /
_cDoaa Ezzat Said Ahmed ; Supervised Hosam Kamel , Amr Saad Elsaid , Mahmoud Ahmed Mansour
246 1 5 _aدراسة عن بعض المؤشرات الكيميائية الحيوية فى مرضى سرطان الدم النخاعى والليمفاوى
260 _aCairo :
_bDoaa Ezzat Said Ahmed ,
_c2006
300 _a213P :
_bcharts ;
_c30cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department Of Biochemistry
520 _aThis work has been carried out to investigate the lipid peroxidation and the status of antioxidants in patients with acute myeloid leukemia (AML) , chronic myeloid leukemia (CML) , acute lymphoid leukemia (ALL) , chronic lymphoid leukemia (CLL) Reduced glutathione (GSH) , lipid peroxidation product such as malondialdhyde (MDA) , glutathione peroxidase (GSH - Px) , glutathione - S - transferase (GST) , catalase (CAT) , total lactate dehydrogenase (LDH) and ferritin were determined in 59 patients with lymphoid leukemia (ALL , CLL) and myeloid leukemia (AML , CML) and 15 healthy controls Reduced glutathione concentration was significantly lower in all types of leukemia Moreover , serum CAT and GSH - PX activities were significantly inhibited in myeloid leukemia (AML , CML) and CLL respectively In contrast GST and LDH activities were higher in myeloid leukemia (AML , CML) Serum MDA and ferritin level were significantly elevated in all types of leukemia as compared to control groups There were no differences for parameters cited above between treated and untreated groups of different types of leukemias , suggesting a predominant oxidative stress status which may lead to enhanced action of oxygen radicals , resulting in lipid peroxidation
530 _aIssued also as CD
653 4 _aLipid peroxides
653 4 _aOxidative stress
653 4 _aReduced glutathione
700 0 _aAmr Saad Elsaid ,
_eSupervisor
700 0 _aHosam Kamel ,
_eSupervisor
700 0 _aMahmoud Ahmed Mansour ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aEsam
_eRevisor
942 _2ddc
_cTH
999 _c26224
_d26224