000 01927cam a2200349 a 4500
003 EG-GiCUC
005 20250223030741.0
008 130120s2012 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.04.M.Sc.2012.Sa.S
100 0 _aSara Shaban Ibrahim Mohamed
245 1 0 _aSynthesis of new thiazole derivatives bearing a sulfonamide moiety of expected anticancer and radiosensitizing activities /
_cSara Shaban Ibrahim Mohamed ; Supervised Mohamed Abdelrahman Shaaban , Helmy Imail Heiba , Hanan Mohamed Refaat
246 1 5 _aتحضير مشتقات الثيازول الجديدة والتى تحتوى على مجموعة السلفوناميد والمتوقع لها نشاطا كمضادات للسرطان وكمحفزات للاشعاع
260 _aCairo :
_bSara Shaban Ibrahim Mohamed ,
_c2012
300 _a123P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
520 _aIn a search for new cytotoxic agents with improved antitumor activity and selectivity , some new pyranothiazole and thiazolopyranopyimidine derivatives bearing sulfonamide moiety were synthesized . The newly synthesized compounds were evaluated for their antitumor activity alone and in combination with y - irradiation . These new compounds were docked inside the active site of carbonic anhydrase II to predict their mechanism of action
530 _aIssued also as CD
653 4 _aAnticancer
653 4 _aSulfonamide
653 4 _aThiazole
700 0 _aHanan Mohamed Refaat ,
_eSupervisor
700 0 _aHelmy Imail Heiba ,
_eSupervisor
700 0 _aMohamed Abdelrahman Shaaban ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aFatma
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c41174
_d41174