| 000 | 01647cam a2200277 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223030813.0 | ||
| 008 | 130327s2010 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aGift | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.34.M.Sc.2010.Na.D | ||
| 100 | 0 | _aNancy Maher Riad Girgis | |
| 245 | 1 | 0 |
_aDesign and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents / _cNancy Maher Riad Girgis ; Supervised Ashraf H. Abadi |
| 246 | 1 | 5 | _aتصميم وتشييد مشتقات جديدة من البيتا كاربولين مثبطات لإنزيم فوسفودايستراز 5 ومضادات للسرطان |
| 260 |
_aCairo : _bNancy Maher Riad Girgis , _c2010 |
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| 300 |
_a138Leaves : _bcharts , facsimiles ; _c30cm |
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| 502 | _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry | ||
| 520 | _aTadalfil is one of the widely marketed medications for the treatment of male erectile dysfunction . Despite its potency and efficacy it is still not free from side effects and its cross reactivity with other phosphodiesterases particularly PDE11 is still a point of question . Moreover many recent studies have showed that PDE5 and other PDEs are over - expressed in malignant tumor cells thus inhibiting PDEs action may be related to anticancer and apoptotic activities | ||
| 700 | 0 |
_aAshraf H. Abadi , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c42269 _d42269 |
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